The effect of CPAP on obstructive sleep apnea hypopnea syndrome during pregnancy

Objective: The study aimed to explore the curative effect of continuous positive airway pressure (CPAP) on obstructive sleep apnea hypopnea syndrome (OSAHS) in pregnant women. Method: Women diagnosed with OSAHS were recruited as the study cohort from June 2013 to May 2016 in our hospital. Their basic clinicopathological data were recorded, and polysomnography respiratory monitoring and CPAP therapy were performed. Serum samples were collected from the women and statistically analyzed. Results: According to the analysis of the cohort's clinicopathological data, there were more patients with severe diseases than there were with mild symptoms, with a significant difference. A further correlation analysis of various indexes including lactic acid and pH value showed that the levels of lactic acid in the patients were positively correlated with age and average SpO(2) (oxygen saturation) level, negatively correlated with neck circumference, their apnea-hypopnea index (AHI) classification, and the oxygen desaturation index (ODI) level, with significant differences (P<0.05). There was no significant correlation between the lactic acid content and body mass index (BMI), waist circumference, or LaO2. In the correlation analysis between the pH values of the OSAHS patients and other indicators, it was found that the pH value of the OSAHS patients was positively correlated with age and neck circumference and negatively correlated with ODI, with a significant difference (P<0.05). The correlation between pH value and BMI, waist circumference, AHI classification, LaO2, and average SpO(2) was not significant, and there was no significant difference. After the CPAP treatment, the AHI, ODI, and lactic acid levels were significantly reduced, with statistically significant differences compared with the levels before the CPAP treatment (P<0.01). After the CPAP treatment, the LaO2, average SpO(2), pH value, and PaO2 levels were significantly increased, with statistically significant differences compared with before the treatment (P<0.01). Conclusion: CPAP treatment for OSAHS patients can effectively improve blood lactic acid and pH levels.