The Role of Cytokines in the Regulation of Neurotransmission

被引：51

作者：

Camacho-Arroyo, I. ^{[2
]}

Lopez-Griego, L. ^{[1
]}

Morales-Montor, J. ^{[1
]}

机构：

[1] Univ Nacl Autonoma Mexico, Inst Invest Biomed, Dept Inmunol, Mexico City 04510, DF, Mexico

[2] Univ Nacl Autonoma Mexico, Fac Quim, Dept Biol, Mexico City 04510, DF, Mexico

来源：

NEUROIMMUNOMODULATION | 2009年 / 16卷 / 01期

关键词：

Central nervous system; Cytokines; Immune system; Neuroimmune network; Neuroimmunoendocrine function; Neurotransmission; NECROSIS-FACTOR-ALPHA; CENTRAL-NERVOUS-SYSTEM; CEREBELLAR PURKINJE NEURONS; RAT HIPPOCAMPAL-NEURONS; GAMMA GENE-EXPRESSION; IL-6R MESSENGER-RNAS; LONG-TERM DEPRESSION; INTERFERON-GAMMA; TRANSGENIC MICE; TNF-ALPHA;

D O I：

10.1159/000179661

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

Cytokines are highly inducible, secretory proteins that mediate intercellular communication in the immune system. They are grouped in several protein families, namely tumor necrosis factors, interleukins, interferons and colony-stimulating factors. In recent years, evidence has elucidated that some of these proteins as well as their receptors are also produced in the central nervous system (CNS) by specific neural cell lineages under physiological and pathological conditions. Cytokines regulate a variety of processes in the CNS, including neurotransmission. The current data let us to suggest that cytokines play an important role in the regulation of both excitatory and inhibitory neurotransmission in the CNS. This knowledge could be fundamental for the proposal of new therapeutic approaches to neurological and psychiatric disorders. Copyright (C) 2008 S. Karger AG, Basel

引用

页码：1 / 12

页数：12

共 117 条

[1] The blockade of IL-6 signaling in rational drug design [J].

Adachi, Yasuo ;

Yoshio-Hoshino, Naoko ;

Nishimoto, Norihiro .

CURRENT PHARMACEUTICAL DESIGN, 2008, 14 (12) :1217-1224

[2] Oligodendrocyte apoptosis and primary demyelination induced by local TNF/p55TNF receptor signaling in the central nervous system of transgenic mice - Models for multiple sclerosis with primary oligodendrogliopathy [J].

Akassoglou, K ;

Bauer, J ;

Kassiotis, G ;

Pasparakis, M ;

Lassmann, H ;

Kollias, G ;

Probert, L .

AMERICAN JOURNAL OF PATHOLOGY, 1998, 153 (03) :801-813

[3] Interleukin-1β modulates state-dependent discharge activity of preoptic area and basal forebrain neurons:: role in sleep regulation [J].

Alam, MN ;

McGinty, D ;

Bashir, T ;

Kumar, S ;

Imeri, L ;

Opp, MR ;

Szymusiak, R .

EUROPEAN JOURNAL OF NEUROSCIENCE, 2004, 20 (01) :207-216

[4] INTERLEUKIN-2 MODULATES EVOKED RELEASE OF [H-3] DOPAMINE IN RAT CULTURED MESENCEPHALIC CELLS [J].

ALONSO, R ;

CHAUDIEU, I ;

DIORIO, J ;

KRISHNAMURTHY, A ;

QUIRION, R ;

BOKSA, P .

JOURNAL OF NEUROCHEMISTRY, 1993, 61 (04) :1284-1290

[5] Activation of metabotropic glutamate receptor 3 enhances interleukin (IL)-1β-stimulated release of IL-6 in cultured human astrocytes [J].

Aronica, E ;

Gorter, JA ;

Rozemuller, AJ ;

Yankaya, B ;

Troost, D .

NEUROSCIENCE, 2005, 130 (04) :927-933

[6]

BENVENISTE EN, 1994, J IMMUNOL, V153, P5210

[7] Cytokine actions in the central nervous system [J].

Benveniste, EN .

CYTOKINE & GROWTH FACTOR REVIEWS, 1998, 9 (3-4) :259-275

[8]

Besedovsky HO, 2002, FRONT HORM RES, V29, P1

[9] Immune-neuro-endocrine interactions: Facts and hypotheses [J].

Besedovsky, HO ;

DelRey, A .

ENDOCRINE REVIEWS, 1996, 17 (01) :64-102

[10]

Besedovsky HO, 2000, Z RHEUMATOL, V59, P26, DOI 10.1007/s003930070014

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