Brain MRI correlates of magnetization transfer imaging metrics in patients with multiple sclerosis

被引:25
作者
Rovaris, M
Bozzali, M
Rodegher, M
Tortorella, C
Comi, G
Filippi, M
机构
[1] Univ Milan, Osped San Raffaele, Inst Sci, Dept Neurosci,Neuroimaging Res Unit, I-20132 Milan, Italy
[2] Univ Milan, Osped San Raffaele, Inst Sci, Dept Neurosci,Clin Trials Unit, I-20132 Milan, Italy
关键词
multiple sclerosis; magnetic resonance imaging; magnetization transfer imaging; magnetization transfer ratio histograms; disease burden; brain atrophy;
D O I
10.1016/S0022-510X(99)00113-6
中图分类号
R74 [神经病学与精神病学];
学科分类号
摘要
Previous studies suggested that magnetization transfer ratio (MTR) histograms are highly correlated with other magnetic resonance imaging (MRI) measures and can be used as a reliable method for quantifying overall disease burden in multiple sclerosis (MS). However, the relative influence of burden and severity of macroscopic MS lesions and degree of brain atrophy on various MTR histogram parameters has not yet been fully elucidated. Aim of the present study was to investigate which MRI measure best predicts the values of MTR histogram parameters in MS patients. Forty-two MS patients underwent brain dual-echo, T1-weighted and magnetization transfer imaging (MTI) MRI scans. Hyperintense lesion load (LL) on proton density (PD)-weighted and hypointense LL on T1-weighted images were measured using a local thresholding technique. A measure of brain atrophy was derived from T1-weighted images by computing the volume of brain tissue segmented from a slab of five consecutive slices rostral to the velum interpositum. On MTI scans, MTR histogram analysis was performed for the whole brain and average lesion MTR was also calculated. PD-weightcd LL, T1-weighted LL and brain volume were significantly correlated with several MTI-derived measures. When a multivariate analysis was performed, brain volume alone significantly predicted the values of all the MTR histogram-derived measures (P values ranged from 0.093 to 0.0002). The ratio between hypointense T1-weighted and hyperintense PD-weighted LL significantly predicted average lesion MTR (P<0.05), Our results confirm that MTR can be used as a reliable method to assess both the overall disease burden and the individual lesion intrinsic nature in MS patients. The significant influence of brain atrophy on MTR histogram parameters supports the concept that this method also provides information on the loss of brain parenchyma in MS. (C) 1999 Elsevier Science B.V. All rights reserved.
引用
收藏
页码:58 / 63
页数:6
相关论文
共 30 条
  • [1] DOUSSET V, 1995, AM J NEURORADIOL, V16, P225
  • [2] EXPERIMENTAL ALLERGIC ENCEPHALOMYELITIS AND MULTIPLE-SCLEROSIS - LESION CHARACTERIZATION WITH MAGNETIZATION TRANSFER IMAGING
    DOUSSET, V
    GROSSMAN, RI
    RAMER, KN
    SCHNALL, MD
    YOUNG, LH
    GONZALEZSCARANO, F
    LAVI, E
    COHEN, JA
    [J]. RADIOLOGY, 1992, 182 (02) : 483 - 491
  • [3] A MAGNETIZATION-TRANSFER IMAGING STUDY OF NORMAL-APPEARING WHITE-MATTER IN MULTIPLE-SCLEROSIS
    FILIPPI, M
    CAMPI, A
    DOUSSET, V
    BARATTI, C
    MARTINELLI, V
    CANAL, N
    SCOTTI, G
    COMI, G
    [J]. NEUROLOGY, 1995, 45 (03) : 478 - 482
  • [4] Comparison of MS clinical phenotypes using conventional and magnetization transfer MRI
    Filippi, M
    Iannucci, G
    Tortorella, C
    Minicucci, L
    Horsfield, MA
    Colombo, B
    Sormani, MP
    Comi, G
    [J]. NEUROLOGY, 1999, 52 (03) : 588 - 594
  • [5] Quantitative volumetric analysis of brain magnetic resonance imaging from patients with multiple sclerosis
    Filippi, M
    Mastronardo, G
    Rocca, MA
    Pereira, C
    Comi, G
    [J]. JOURNAL OF THE NEUROLOGICAL SCIENCES, 1998, 158 (02) : 148 - 153
  • [6] Magnetic resonance imaging in the differential diagnosis and monitoring of the treatment of multiple sclerosis
    Filippi, M
    Miller, DH
    [J]. CURRENT OPINION IN NEUROLOGY, 1996, 9 (03) : 178 - 186
  • [7] CORRELATION OF MAGNETIZATION-TRANSFER RATIO WITH CLINICAL DISABILITY IN MULTIPLE-SCLEROSIS
    GASS, A
    BARKER, GJ
    KIDD, D
    THORPE, JW
    MACMANUS, D
    BRENNAN, A
    TOFTS, PS
    THOMPSON, AJ
    MCDONALD, WI
    MILLER, DH
    [J]. ANNALS OF NEUROLOGY, 1994, 36 (01) : 62 - 67
  • [8] MAGNETIZATION-TRANSFER IN MULTIPLE-SCLEROSIS
    GROSSMAN, RI
    [J]. ANNALS OF NEUROLOGY, 1994, 36 : S97 - S99
  • [9] HIEHLE JF, 1995, AM J NEURORADIOL, V16, P69
  • [10] KURTZKE JF, 1983, NEUROLOGY, V33, P1444, DOI 10.1212/WNL.33.11.1444