Activity of the mitochondrial multiple conductance channel is independent of the adenine nucleotide translocator

被引：0
|
作者：
Lohret, TA
Murphy, RC
Drgon, T
Kinnally, KW
机构：
[1] NEW YORK STATE DEPT HLTH,WADSWORTH CTR LABS & RES,DIV MOLEC MED,ALBANY,NY 12201
[2] SUNY ALBANY,DEPT BIOMED SCI,ALBANY,NY 12222
[3] SUNY ALBANY,DEPT BIOL SCI,ALBANY,NY 12222
[4] COMENIUS UNIV BRATISLAVA,DEPT BIOCHEM,BRATISLAVA 84215,SLOVAKIA
来源：
JOURNAL OF BIOLOGICAL CHEMISTRY | 1996年 / 271卷 / 09期
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D O I：
暂无
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The functional relationship between the adenine nucleotide translocator (ANT) and the mitochondrial multiple conductance channel (MCC) was investigated using patch-clamp techniques. MCC activity with the same conductance, ion selectivity, voltage dependence, and peptide sensitivity could be reconstituted from inner membrane fractions derived from mitochondria of ANT-deficient and wild-type Saccharomyces cerevisiae. In addition, the MCC activity of mouse kidney mitoplasts was unaffected by carboxyatractyloside, a known inhibitor of ANT and inducer of a permeability transition. These results suggest that MCC activity is independent of ANT.
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页码：4846 / 4849
页数：4
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