Multimodal near infrared spectral imaging as an exploratory tool for dysplastic esophageal lesion identification

We explore nine different combinations of fluorescence, light scattering, and polarization spectral imaging approaches in the near- infrared spectral region toward the diagnosis of pathologic and normal esophageal lesions. The combinations of all the imaging techniques were evaluated for maximal sensitivity and specificity. The results suggest that this multimodal approach is capable of highly accurate detection of the presence of pathologic tissue. (c) 2006 Optical Society of America.