Myokines: Novel therapeutic targets for diabetic nephropathy

被引：7
|
作者：
Yang, Ming [1 ,2 ]
Luo, Shilu [2 ]
Yang, Jinfei [2 ]
Chen, Wei [2 ]
He, Liyu [2 ]
Liu, Di [2 ]
Zhao, Li [3 ]
Wang, Xi [1 ,4 ]
机构：
[1] Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Hunan, Peoples R China
[2] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China
[3] Kunming Med Univ, Affiliated Hosp 1, Dept Reprod & Genet, Kunming, Peoples R China
[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China
来源：
FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷
基金：
中国国家自然科学基金;
关键词：
myokines; diabetic nephropathy; muscle; irisin; FGF21; GROWTH-FACTOR; 21; GLOMERULAR-FILTRATION-RATE; ACID-BINDING PROTEIN-3; SKELETAL-MUSCLE; INFLAMMATORY MARKERS; ECCENTRIC EXERCISE; PHYSICAL-ACTIVITY; ENDOCRINE ORGAN; FGF21; IRISIN;
D O I：
10.3389/fendo.2022.1014581
中图分类号：
R5 [内科学];
学科分类号：
1002 ; 100201 ;
摘要：
With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported. Muscle is not only an important motor organ but also an important endocrine organ, secreting a group of proteins called "myokines" into the blood circulation. Circulating myokines then move to various target organs to play different biological roles. In this review, we summarize the currently known myokines and the progress in research relating them to DN and discuss its potential as a therapeutic target for DN.
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收藏
页数：10
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