Myokines: Novel therapeutic targets for diabetic nephropathy

被引：7

作者：

Yang, Ming ^{[1
,2
]}

Luo, Shilu ^{[2
]}

Yang, Jinfei ^{[2
]}

Chen, Wei ^{[2
]}

He, Liyu ^{[2
]}

Liu, Di ^{[2
]}

Zhao, Li ^{[3
]}

Wang, Xi ^{[1
,4
]}

机构：

[1] Cent South Univ, Xiangya Hosp, Dept Nutr, Changsha, Hunan, Peoples R China

[2] Cent South Univ, Xiangya Hosp 2, Dept Nephrol, Changsha, Peoples R China

[3] Kunming Med Univ, Affiliated Hosp 1, Dept Reprod & Genet, Kunming, Peoples R China

[4] Cent South Univ, Xiangya Hosp, Natl Clin Res Ctr Geriatr Disorders, Changsha, Peoples R China

来源：

FRONTIERS IN ENDOCRINOLOGY | 2022年 / 13卷

基金：

中国国家自然科学基金;

关键词：

myokines; diabetic nephropathy; muscle; irisin; FGF21; GROWTH-FACTOR; 21; GLOMERULAR-FILTRATION-RATE; ACID-BINDING PROTEIN-3; SKELETAL-MUSCLE; INFLAMMATORY MARKERS; ECCENTRIC EXERCISE; PHYSICAL-ACTIVITY; ENDOCRINE ORGAN; FGF21; IRISIN;

D O I：

10.3389/fendo.2022.1014581

中图分类号：

R5 [内科学];

学科分类号：

1002 ; 100201 ;

摘要：

With the increasing incidence of diabetic nephropathy (DN), there is an urgent need to find effective DN preventive and therapeutic modalities. It is widely believed that effective exercise is good for health. However, the beneficial role of exercise in kidney disease, especially in DN, and the underlying molecular mechanisms have rarely been reported. Muscle is not only an important motor organ but also an important endocrine organ, secreting a group of proteins called "myokines" into the blood circulation. Circulating myokines then move to various target organs to play different biological roles. In this review, we summarize the currently known myokines and the progress in research relating them to DN and discuss its potential as a therapeutic target for DN.

引用

页数：10

共 50 条

[1] Diabetic Nephropathy: Novel Molecular Mechanisms and Therapeutic Targets
Zoja, Carlamaria
Xinaris, Christodoulos
Macconi, Daniela
FRONTIERS IN PHARMACOLOGY, 2020, 11
[2] Recent therapeutic targets in diabetic nephropathy
Mohsen, Marwa
Elberry, Ahmed A.
Rabea, Alaa Mohamed
Abdelrahim, Mohamed E. A.
Hussein, Raghda R. S.
INTERNATIONAL JOURNAL OF CLINICAL PRACTICE, 2021, 75 (11)
[3] Novel approaches and therapeutic targets for diabetic nephropathy: Advances and promising strategies
Ubhenin, Abraham Ehinomhen
Ikebuiro, Joshua Onyeka
Anura, Fatima
Idris, Ramatu Iya
Erharuyi, Osayemwenre
TROPICAL JOURNAL OF PHARMACEUTICAL RESEARCH, 2023, 22 (12) : 2567 - 2574
[4] Diabetic nephropathy: New insights into established therapeutic paradigms and novel molecular targets
Sharma, Dilip
Bhattacharya, Pallab
Kalia, Kiran
Tiwari, Vinod
DIABETES RESEARCH AND CLINICAL PRACTICE, 2017, 128 : 91 - 108
[5] MicroRNAs in diabetic nephropathy: functions, biomarkers, and therapeutic targets
Kato, Mitsuo
Natarajan, Rama
YEAR IN DIABETES AND OBESITY, 2015, 1353 : 72 - 88
[6] Searching for novel biornarkers and new therapeutic targets of diabetic nephropathy using proteornics approaches
Thongboonkerd, Visith
PROTEOMICS IN NEPHROLOGY - TOWARDS CLINICAL APPLICATIONS, 2008, 160 : 37 - 52
[7] Combining mitochondrial proteomes and Mendelian randomization to identify novel therapeutic targets for diabetic nephropathy
Liu, Yang
Wu, Rong
Zhou, Zhelun
Zhou, Junan
Zhang, Jiaai
Wang, Xiaoyi
RENAL FAILURE, 2025, 47 (01)
[8] Myokines as Possible Therapeutic Targets in Cancer Cachexia
Manole, Emilia
Ceafalan, Laura C.
Popescu, Bogdan O.
Dumitru, Carmen
Bastian, Alexandra E.
JOURNAL OF IMMUNOLOGY RESEARCH, 2018, 2018
[9] Mitochondria: A Novel Therapeutic Target in Diabetic Nephropathy
Yang, Shikun
Han, Yachun
Liu, Jun
Song, Panai
Xu, Xiaoxuan
Zhao, Li
Hu, Chun
Xiao, Li
Liu, Fuyou
Zhang, Hao
Sun, Lin
CURRENT MEDICINAL CHEMISTRY, 2017, 24 (29) : 3185 - 3202
[10] Novel mechanisms and therapeutic options in diabetic nephropathy
Miyata, Toshio
POLSKIE ARCHIWUM MEDYCYNY WEWNETRZNEJ-POLISH ARCHIVES OF INTERNAL MEDICINE, 2009, 119 (04): : 261 - 263

← 1 2 3 4 5 →