Highly chemoselective reduction using a Rh/C-Fe(OAc)2 system:: practical synthesis of functionalized indoles

被引：29
作者：
Akao, A
Sato, K
Nonoyama, N
Mase, T
Yasuda, N
机构：
[1] Banyu Pharmaceut Co Ltd, Okazaki, Aichi 4440858, Japan
[2] Merck Res Labs, Dept Proc Res, Rahway, NJ 07065 USA
来源：
TETRAHEDRON LETTERS | 2006年 / 47卷 / 06期
关键词：
D O I：
10.1016/j.tetlet.2005.11.145
中图分类号：
O62 [有机化学];
学科分类号：
070303 ; 081704 ;
摘要：
Here, we report a highly effective and chemoselective method of preparing substituted indoles from (E)-2-nitropyrrolidinostyrenes via hydrogenation in the presence of a rhodium catalyst doped by additives such as Ni(NO3)(2)(.)6H(2)O, Fe(OAc)(2) or Co(acac)(3). These hydrogenation conditions may also be applied to other substrates. Aromatic nitro compounds and olefins can be selectively reduced in the presence of aromatic benzyl ethers, aromatic halides and aromatic aldehydes. (c) 2005 Elsevier Ltd. All rights reserved.
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收藏
页码：969 / 972
页数：4
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