SYNTHESIS CHARACTERIZATION AND BIOLOGICAL EVALUATION OF NOVEL 1-(5-((3,5-DIMETHYL-4-((4-(TRIFLUOROMETHYL)PHENYL)DIAZENYL)-1H-PYRAZOL-1-YL)METHYL)-2-METHYL-2-PHENYL-1,3,4-OXADIAZOL-3(2H)-YL)ETHANONE

The article is aimed to synthesize,characterize and screening the biological activity of 1-(5-((3,5-dimethyl-4-((4-(trifluoromethyl)phenyl)diazenyl)-1H-pyrazol-1-yl)methyl)-2methyl-2-phenyl-1,3,4-oxadiazol-3(2H)-yl)ethanone 8(a-f). 1-Chloro-2-phenyldiazene and pentane-2,4-dione were dissolved in DMF.To this reaction mixture anhydrous K2CO3 was added and the reaction mixture was stirred at room temperature(35 degrees C) for 8 hours .To afford 3-(phenylamino)pentane-2,4-dione. To this reaction mixture added Hydrazine hydride,chloroethyl acetate,acetophenone,EtoH and three drops of acetic acid is added and then heated on a steam bath for 5-6 hrs.To obtain 2-(3,5-dimethyl-4-((4-(trifluoromethyl)phenyl)diazenyl)-1H-pyrazol -1-yl)-N'-(1-phenyl ethylidene)acetohydrazi de Compound(7).Finally compound 7(a) is treated with acetic anhydride to obtained target molecule 1-(5-((3,5-dimethyl-4-((4-(trifluoromethyl)phenyl)diazenyl)-1H-pyrazol-1-yl)methyl)-2-methyl-2-phenyl-1,3,4-oxadiazol-3(2H)-yl)ethanone. The structure of these newly synthesized compounds were characterised by H-1 NMR, (CNMR)-C-13 ,Mass ,IR, and elemental analysis. The antimicriobial activity of the novel compounds was screened by agar disc diffusion method.