Genetics of Pancreatic Cancer and Its Implications on Therapy

被引：13
作者：
Tatarian, Talar [1 ]
Winter, Jordan M. [2 ]
机构：
[1] Thomas Jefferson Univ Hosp, Dept Surg, Jefferson Pancreas Biliary & Related Canc Ctr, Sidney Kimmel Med Coll, 1015 Walnut St,Suite 620, Philadelphia, PA 19107 USA
[2] Thomas Jefferson Univ Hosp, Dept Surg, Jefferson Pancreas Biliary & Related Canc Ctr, Sidney Kimmel Med Coll, 1025 Walnut St,Suite 605, Philadelphia, PA 19107 USA
来源：
SURGICAL CLINICS OF NORTH AMERICA | 2016年 / 96卷 / 06期
关键词：
Pancreatic cancer; Genetics; Personalized medicine; Targeted therapy; PHASE-II TRIAL; GROWTH-FACTOR RECEPTOR; DUCTAL ADENOCARCINOMA; 1ST-LINE TREATMENT; PLUS GEMCITABINE; OPEN-LABEL; K-RAS; MUTATIONS; TRASTUZUMAB; KRAS;
D O I：
10.1016/j.suc.2016.07.014
中图分类号：
R61 [外科手术学];
学科分类号：
摘要：
Over the past decade, emerging technologies have provided new insights into the genomic landscape of pancreatic ductal adenocarcinoma (PDA). In addition to the commonly recognized genetic drivers of pancreatic carcinogenesis (KRAS, CDKN2A, TP53, SMAD4), new genes and pathways have been implicated. However, these efforts have not identified any new high-frequency actionable mutations, limiting the success of mutation-targeted therapy in PDA. This article provides a report on the current landscape of pancreas cancer genetics and targeted therapeutics.
引用
收藏
页码：1207 / +
页数：16
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