Child Development and Molecular Genetics: 14 Years Later

被引：57

作者：

Plomin, Robert ^{[1
]}

机构：

[1] Kings Coll London, Inst Psychiat, MRC Social Genet & Dev Psychiat Ctr, London SE5 8AF, England

来源：

CHILD DEVELOPMENT | 2013年 / 84卷 / 01期

基金：

英国医学研究理事会;

关键词：

GENOME-WIDE ASSOCIATION; GENERAL COGNITIVE-ABILITY; DEFICIT HYPERACTIVITY DISORDER; RARE CHROMOSOMAL DELETIONS; ORIGIN ALLELIC EXPRESSION; COPY NUMBER VARIATION; COMMON SNPS EXPLAIN; MISSING HERITABILITY; DNA-METHYLATION; COMPLEX TRAITS;

D O I：

10.1111/j.1467-8624.2012.01757.x

中图分类号：

G44 [教育心理学];

学科分类号：

0402 ; 040202 ;

摘要：

Fourteen years ago, the first article on molecular genetics was published in this journal: Child Development, Molecular Genetics, andWhat to Do With Genes Once They Are Found (R. Plomin & M. Rutter, 1998). The goal of the article was to outline what developmentalists can do with genes once they are found. These new directions for developmental research are still relevant today. The problem lies with the phrase once they are found: It has been much more difficult than expected to identify genes responsible for the heritability of complex traits and common disorders, the so-called missing heritability problem. The present article considers reasons for the missing heritability problem and possible solutions.

引用

页码：104 / 120

页数：17

共 140 条

[1] Annotating non-coding regions of the genome [J].

Alexander, Roger P. ;

Fang, Gang ;

Rozowsky, Joel ;

Snyder, Michael ;

Gerstein, Mark B. .

NATURE REVIEWS GENETICS, 2010, 11 (08) :559-571

[2] Hundreds of variants clustered in genomic loci and biological pathways affect human height [J].

Allen, Hana Lango ;

Estrada, Karol ;

Lettre, Guillaume ;

Berndt, Sonja I. ;

Weedon, Michael N. ;

Rivadeneira, Fernando ;

Willer, Cristen J. ;

Jackson, Anne U. ;

Vedantam, Sailaja ;

Raychaudhuri, Soumya ;

Ferreira, Teresa ;

Wood, Andrew R. ;

Weyant, Robert J. ;

Segre, Ayellet V. ;

Speliotes, Elizabeth K. ;

Wheeler, Eleanor ;

Soranzo, Nicole ;

Park, Ju-Hyun ;

Yang, Jian ;

Gudbjartsson, Daniel ;

Heard-Costa, Nancy L. ;

Randall, Joshua C. ;

Qi, Lu ;

Smith, Albert Vernon ;

Maegi, Reedik ;

Pastinen, Tomi ;

Liang, Liming ;

Heid, Iris M. ;

Luan, Jian'an ;

Thorleifsson, Gudmar ;

Winkler, Thomas W. ;

Goddard, Michael E. ;

Lo, Ken Sin ;

Palmer, Cameron ;

Workalemahu, Tsegaselassie ;

Aulchenko, Yurii S. ;

Johansson, Asa ;

Zillikens, M. Carola ;

Feitosa, Mary F. ;

Esko, Tonu ;

Johnson, Toby ;

Ketkar, Shamika ;

Kraft, Peter ;

Mangino, Massimo ;

Prokopenko, Inga ;

Absher, Devin ;

Albrecht, Eva ;

Ernst, Florian ;

Glazer, Nicole L. ;

Hayward, Caroline .

NATURE, 2010, 467 (7317) :832-838

[3] A map of human genome variation from population-scale sequencing [J].

Altshuler, David ;

Durbin, Richard M. ;

Abecasis, Goncalo R. ;

Bentley, David R. ;

Chakravarti, Aravinda ;

Clark, Andrew G. ;

Collins, Francis S. ;

De la Vega, Francisco M. ;

Donnelly, Peter ;

Egholm, Michael ;

Flicek, Paul ;

Gabriel, Stacey B. ;

Gibbs, Richard A. ;

Knoppers, Bartha M. ;

Lander, Eric S. ;

Lehrach, Hans ;

Mardis, Elaine R. ;

McVean, Gil A. ;

Nickerson, DebbieA. ;

Peltonen, Leena ;

Schafer, Alan J. ;

Sherry, Stephen T. ;

Wang, Jun ;

Wilson, Richard K. ;

Gibbs, Richard A. ;

Deiros, David ;

Metzker, Mike ;

Muzny, Donna ;

Reid, Jeff ;

Wheeler, David ;

Wang, Jun ;

Li, Jingxiang ;

Jian, Min ;

Li, Guoqing ;

Li, Ruiqiang ;

Liang, Huiqing ;

Tian, Geng ;

Wang, Bo ;

Wang, Jian ;

Wang, Wei ;

Yang, Huanming ;

Zhang, Xiuqing ;

Zheng, Huisong ;

Lander, Eric S. ;

Altshuler, David L. ;

Ambrogio, Lauren ;

Bloom, Toby ;

Cibulskis, Kristian ;

Fennell, Tim J. ;

Gabriel, Stacey B. .

NATURE, 2010, 467 (7319) :1061-1073

[4]

[Anonymous], 2006, GENES BEHAV

[5]

[Anonymous], 2010, Ensouling Language: On the Art of Nonfiction and the Writer's Life

[6]

[Anonymous], NY TIMES MAGAZINE

[7] Predicting human height by Victorian and genomic methods [J].

Aulchenko, Yurii S. ;

Struchalin, Maksim V. ;

Belonogova, Nadezhda M. ;

Axenovich, Tatiana I. ;

Weedon, Michael N. ;

Hofman, Albert ;

Uitterlinden, Andre G. ;

Kayser, Manfred ;

Oostra, Ben A. ;

van Duijn, Cornelia M. ;

Janssens, A. Cecile J. W. ;

Borodin, Pavel M. .

EUROPEAN JOURNAL OF HUMAN GENETICS, 2009, 17 (08) :1070-1075

[8] Direct Measure of the De Novo Mutation Rate in Autism and Schizophrenia Cohorts [J].

Awadalla, Philip ;

Gauthier, Julie ;

Myers, Rachel A. ;

Casals, Ferran ;

Hamdan, Fadi F. ;

Griffing, Alexander R. ;

Cote, Melanie ;

Henrion, Edouard ;

Spiegelman, Dan ;

Tarabeux, Julien ;

Piton, Amelie ;

Yang, Yan ;

Boyko, Adam ;

Bustamante, Carlos ;

Xiong, Lan ;

Rapoport, Judith L. ;

Addington, Aniene M. ;

DeLisi, J. Lynn E. ;

Krebs, Marie-Odile ;

Joober, Ridha ;

Millet, Bruno ;

Fombonne, Eric ;

Mottron, Laurent ;

Zilversmit, Martine ;

Keebler, Jon ;

Daoud, Hussein ;

Marineau, Claude ;

Roy-Gagnon, Marie-Helene ;

Dube, Marie-Pierre ;

Eyre-Walker, Adam ;

Drapeau, Pierre ;

Stone, Eric A. ;

Lafreniere, Ronald G. ;

Rouleau, Guy A. .

AMERICAN JOURNAL OF HUMAN GENETICS, 2010, 87 (03) :316-324

[9] Five common gene variants identify elevated genetic risk for coronary heart disease [J].

Bare, Lance A. ;

Morrison, Alanna C. ;

Rowland, Charles M. ;

Shiffman, Dov ;

Luke, May M. ;

Iakoubova, Olga A. ;

Kane, John P. ;

Malloy, Mary J. ;

Ellis, Stephen G. ;

Pankow, James S. ;

Willerson, James T. ;

Devlin, James J. ;

Boerwinkle, Eric .

GENETICS IN MEDICINE, 2007, 9 (10) :682-689

[10] Genome-wide association defines more than 30 distinct susceptibility loci for Crohn's disease [J].

Barrett, Jeffrey C. ;

Hansoul, Sarah ;

Nicolae, Dan L. ;

Cho, Judy H. ;

Duerr, Richard H. ;

Rioux, John D. ;

Brant, Steven R. ;

Silverberg, Mark S. ;

Taylor, Kent D. ;

Barmada, M. Michael ;

Bitton, Alain ;

Dassopoulos, Themistocles ;

Datta, Lisa Wu ;

Green, Todd ;

Griffiths, Anne M. ;

Kistner, Emily O. ;

Murtha, Michael T. ;

Regueiro, Miguel D. ;

Rotter, Jerome I. ;

Schumm, L. Philip ;

Steinhart, A. Hillary ;

Targan, Stephan R. ;

Xavier, Ramnik J. ;

Libioulle, Cecile ;

Sandor, Cynthia ;

Lathrop, Mark ;

Belaiche, Jacques ;

Dewit, Olivier ;

Gut, Ivo ;

Heath, Simon ;

Laukens, Debby ;

Mni, Myriam ;

Rutgeerts, Paul ;

Van Gossum, Andre ;

Zelenika, Diana ;

Franchimont, Denis ;

Hugot, Jean-Pierre ;

de Vos, Martine ;

Vermeire, Severine ;

Louis, Edouard ;

Cardon, Lon R. ;

Anderson, Carl A. ;

Drummond, Hazel ;

Nimmo, Elaine ;

Ahmad, Tariq ;

Prescott, Natalie J. ;

Onnie, Clive M. ;

Fisher, Sheila A. ;

Marchini, Jonathan ;

Ghori, Jilur .

NATURE GENETICS, 2008, 40 (08) :955-962

← 1 2 3 4 5 6 7 8 9 10 →