Lewis acid-catalyzed Csp3-H functionalization of methyl azaarenes with α-trifluoromethyl carbonyl compounds

被引：59

作者：

Graves, Vincent B. ^{[1
]}

Shaikh, Abid ^{[1
]}

机构：

[1] Georgia So Univ, Dept Chem, Statesboro, GA 30460 USA

来源：

TETRAHEDRON LETTERS | 2013年 / 54卷 / 07期

关键词：

Azaarenes; C-H functionalization; Trifluoromethyl ketone; Catalysis; Lewis acid; C-H BOND; N-SULFONYL ALDIMINES; SITE-SELECTIVE SP(2); DIRECT ARYLATION; OLEFINATION;

D O I：

10.1016/j.tetlet.2012.12.013

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

A Lewis acid promoted Csp(3)-H bond functionalization of methyl azaarenes with alpha-trifluoromethylated carbonyl compounds is described. Catalytic amounts of Yb(OTf)(3) provided a straightforward access to the corresponding trifluoromethylated alcohols in excellent yields up to 94% under mild reaction conditions. Published by Elsevier Ltd.

引用

页码：695 / 698

页数：4

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