Photochemical synthesis and characterization of polyethyleneimine-coated magnetic nanogel used as cancer-targeted carrier

被引：0

作者：

Liu Hong-Ling ^{[1
]}

Li Jun ^{[2
]}

机构：

[1] Dezhou Univ, Dept Med, Dezhou 253023, Peoples R China

[2] Shandong Univ, Sch Publ Hlth, Jinan 250012, Peoples R China

来源：

CHEMICAL JOURNAL OF CHINESE UNIVERSITIES-CHINESE | 2008年 / 29卷 / 08期

关键词：

magnetic nanogels; photochemical preparation; PEI; folate; cancer-targeted carrier;

D O I：

暂无

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The polyethyleneimine (PEI)-coated magnetic nanogel was synthesized via photochemical polymerization under UV-light irradiation. Modified with folic acid, which was expected to be able to Identify tumor surface receptors and to have a high binding force with cancer cells, the FA-PEI-Fe3O4 nanogel was prepared. The FA-PEI-Fe3O4 nanogel was characterized by Fourier transform infrared spectroscopy, thermogravimetric analysis, scan electron microscope and vibrating sample magnetometer, respectively. The results showed that the magnetic nanogel was regular shape with a mean diameter of 140 nm. With high saturation magnetization and folate modification, the FA-PEI-Fe3O4 nanogel suggests promising potential application in cancer-targeted drug delivery.

引用

页码：1703 / 1706

页数：4