Cellular and molecular mechanisms of antimony transport, toxicity and resistance

被引：18

作者：

Tamas, Markus J. ^{[1
]}

机构：

[1] Univ Gothenburg, Dept Chem & Mol Biol, Box 462, S-40530 Gothenburg, Sweden

来源：

ENVIRONMENTAL CHEMISTRY | 2016年 / 13卷 / 06期

基金：

瑞典研究理事会;

关键词：

Acr3; ABC transporter; aquaglyceroporin; arsenic; glutathione; Leishmania; metalloid; yeast; AQUAGLYCEROPORIN AQP1 GENE; TRANSCRIPTION FACTOR YAP8P; ACTIVATED PROTEIN-KINASE; ARSENIC TRIOXIDE UPTAKE; SACCHAROMYCES-CEREVISIAE; PENTAVALENT ANTIMONY; LEISHMANIA-MAJOR; DRUG UPTAKE; PENTAMIDINE RESISTANCE; POTENTIAL RELEVANCE;

D O I：

10.1071/EN16075

中图分类号：

O65 [分析化学];

学科分类号：

070302 ; 081704 ;

摘要：

Antimony is a toxic metalloid that is naturally present in low amounts in the environment, but can locally reach high concentrations at mining and processing sites. Today, antimony is used in a wide range of modern technology applications and is also an important constituent of pharmacological drugs. The increasing use of antimony has led to concerns about human and environmental exposure. Yet little is known about the biological properties of antimony and its mechanisms of actions in cells. This review will provide a brief summary of how antimony enters and affects cells, and how cells deal with the presence of this metalloid to acquire resistance.

引用

页码：955 / 962

页数：8

共 99 条

[1] ARSENIC INDUCES AND ENHANCES RAT HEPATIC METALLOTHIONEIN PRODUCTION INVIVO [J].

ALBORES, A ;

KOROPATNICK, J ;

CHERIAN, MG ;

ZELAZOWSKI, AJ .

CHEMICO-BIOLOGICAL INTERACTIONS, 1992, 85 (2-3) :127-140

[2] Electronic Structures of Antimony Oxides [J].

Allen, Jeremy P. ;

Carey, John J. ;

Walsh, Aron ;

Scanlon, David O. ;

Watson, Graeme W. .

JOURNAL OF PHYSICAL CHEMISTRY C, 2013, 117 (28) :14759-14769

[3]

[Anonymous], [No title captured]

[4] Molecular Basis of Antimony Treatment in Leishmaniasis [J].

Baiocco, Paola ;

Colotti, Gianni ;

Franceschini, Stefano ;

Ilari, Andrea .

JOURNAL OF MEDICINAL CHEMISTRY, 2009, 52 (08) :2603-2612

[5] Identification of Positive Regulators of the Yeast Fps1 Glycerol Channel [J].

Beese, Sara E. ;

Negishi, Takahiro ;

Levin, David E. .

PLOS GENETICS, 2009, 5 (11)

[6] Carcinogenic metal compounds: recent insight into molecular and cellular mechanisms [J].

Beyersmann, Detmar ;

Hartwig, Andrea .

ARCHIVES OF TOXICOLOGY, 2008, 82 (08) :493-512

[7] Drug uptake and pharmacological modulation of drug sensitivity in leukemia by AQP9 [J].

Bhattacharjee, H ;

Carbrey, J ;

Rosen, BP ;

Mukhopadhyay, R .

BIOCHEMICAL AND BIOPHYSICAL RESEARCH COMMUNICATIONS, 2004, 322 (03) :836-841

[8] Metalloids:: essential, beneficial or toxic?: Major intrinsic proteins sort it out [J].

Bienert, Gerd P. ;

Schussler, Manuela D. ;

Jahn, Thomas P. .

TRENDS IN BIOCHEMICAL SCIENCES, 2008, 33 (01) :20-26

[9] A subgroup of plant aquaporins facilitate the bi-directional diffusion of As(OH)3 and Sb(OH)3 across membranes [J].

Bienert, Gerd P. ;

Thorsen, Michael ;

Schussler, Manuela D. ;

Nilsson, Henrik R. ;

Wagner, Annemarie ;

Tamas, Markus J. ;

Jahn, Thomas P. .

BMC BIOLOGY, 2008, 6 (1)

[10]

Bobrowicz P., 1998, Cellular and Molecular Biology Letters, V3, P13

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