Caffeine citrate: when and for how long. A literature review

被引：25

作者：

Picone, S. ^{[1
]}

Bedetta, M. ^{[1
]}

Paolillo, P. ^{[1
]}

机构：

[1] Policlin Casilino Gen Hosp, NICU, Dept Neonatol, I-00169 Rome, Italy

来源：

JOURNAL OF MATERNAL-FETAL & NEONATAL MEDICINE | 2012年 / 25卷

关键词：

Apnoea of prematurity; apnea of prematurity; bronchopulmonary dysplasia; caffeine; neural development; BLOOD-FLOW-VELOCITY; APNEA; THERAPY; PREMATURITY;

D O I：

10.3109/14767058.2012.712305

中图分类号：

R71 [妇产科学];

学科分类号：

100211 ;

摘要：

The efficacy of caffeine in an episode of Apnoea of Prematurity (AOP) has been known for over thirty years. Its use over long periods of time has not only found it to be manageable within the field of neonatology, but it has also been found to have other favourable actions, such as reducing the incidence of extubation failure, preventing Bronchopulmonary Dysplasia (BPD), reducing the need for Patent DuctusArteriosus treatment and the beneficial effect it has on Retinopathy of Prematurity. Recent in vitro trials have highlighted the neuroprotective role that caffeine plays, which has already partly been observed from in vivo trials. Just recently, caffeine citrate has become a "label" drug and it would be beneficial if more studies could confirm the more significant effects it has on the more severe conditions of prematurity.

引用

页码：11 / 14

页数：4

共 27 条

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