Two new triterpenoids from the fungusDiplodia cupressi

被引：11
作者：
Liu, Xiao-Yu [1 ]
Wang, Xiao-Ling [2 ]
Shen, Tao [1 ]
Ren, Dong-Mei [1 ]
Lou, Hong-Xiang [1 ]
Wang, Xiao-Ning [1 ]
机构：
[1] Shandong Univ, Key Lab Chem Biol, Minist Educ, Dept Nat Prod Chem,Sch Pharmaceut Sci, Jinan, Peoples R China
[2] Shandong Univ, Hosp 2, Jinan, Peoples R China
来源：
NATURAL PRODUCT RESEARCH | 2020年 / 34卷 / 15期
基金：
中国国家自然科学基金;
关键词：
Diplodia cupressi; Polytrchum commune; Triterpenoids; Cytotoxic activity; IN-VITRO; ABSOLUTE-CONFIGURATION; PIMARANE DITERPENES; SPHAEROPSIDINS; DERIVATIVES; PRODUCTS; PATHOGEN; COMPLEX; SP;
D O I：
10.1080/14786419.2019.1578762
中图分类号：
O69 [应用化学];
学科分类号：
081704 ;
摘要：
One new pentanortriterpenoid, 23,24,25,26,27-pentanorlanost-7,9(11)-dien-3 beta,22-diol (1), one new triterpenoid, lanost-8-en-3 beta,22S,23S-triol (2), together with the known triterpenoid, 23,24,25,26,27-pentanorlanost-8-en-3 beta,22-diol (3), were obtained from culture of the fungusDiplodia cupressiassociated with the mossPolytrichum commune. The structures of the new compounds were elucidated by extensive spectroscopic techniques including HR-ESIMS and 1 D and 2 D NMR experiments. The cytotoxicity of these compounds against human cancer cell lines (A549, Hep G2, Hepa 1c1c7, and Hela) was evaluated and compound2exhibited weak inhibitory activity with IC(50)value of 35.0 +/- 2.3 mu M against the proliferation of the Hepa 1c1c7 cells.
引用
收藏
页码：2179 / 2185
页数：7
相关论文
共 25 条
  • [1] Fraxitoxin, a New Isochromanone Isolated from Diplodia fraxini
    Cimmino, Alessio
    Maddau, Lucia
    Masi, Marco
    Linaldeddu, Benedetto T.
    Pescitelli, Gennaro
    Evidente, Antonio
    [J]. CHEMISTRY & BIODIVERSITY, 2017, 14 (11)
  • [2] Sphaeropsidone and episphaeropsidone, phytotoxic dimedone methyl ethers produced by Sphaeropsis sapinea f. sp. cupressi grown in liquid culture
    Evidente, A
    Sparapano, L
    Fierro, O
    Bruno, G
    Giordano, F
    Motta, A
    [J]. PHYTOCHEMISTRY, 1998, 48 (07) : 1139 - 1143
  • [3] A phytotoxic pimarane diterpene of Sphaeropsis sapinea f sp cupressi, the pathogen of a canker disease of cypress
    Evidente, A
    Sparapano, L
    Motta, A
    Giordano, F
    Fierro, O
    Frisullo, S
    [J]. PHYTOCHEMISTRY, 1996, 42 (06) : 1541 - 1546
  • [4] Sphaeropsidins D and E, two other pimarane diterpenes, produced in vitro by the plant pathogenic fungus Sphaeropsis sapinea f. sp cupressi
    Evidente, A
    Sparapano, L
    Bruno, G
    Motta, A
    [J]. PHYTOCHEMISTRY, 2002, 59 (08) : 817 - 823
  • [5] Diplofuranones A and B, two further new 4-monosubstituted 2(3H)-dihydrofuranones produced by Diplodia corticola, a fungus pathogen of cork oak
    Evidente, Antonio
    Andolfi, Anna
    Fiore, Michele
    Spanu, Emanuela
    Franceschini, Antonio
    Maddau, Lucia
    [J]. ARKIVOC, 2007, : 318 - 328
  • [6] In Vitro Antibacterial Activity of Sphaeropsidins and Chemical Derivatives toward Xanthomonas oryzae pv. oryzae, the Causal Agent of Rice Bacterial Blight
    Evidente, Antonio
    Venturi, Vittorio
    Masi, Marco
    Degrassi, Giuliano
    Cimmino, Alessio
    Maddau, Lucia
    Andolfi, Anna
    [J]. JOURNAL OF NATURAL PRODUCTS, 2011, 74 (12): : 2520 - 2525
  • [7] Frelek J, 1997, CHIRALITY, V9, P578, DOI 10.1002/(SICI)1520-636X(1997)9:5/6<578::AID-CHIR27>3.3.CO
  • [8] 2-K
  • [9] NEW METABOLIC PRODUCTS OF VERTICILLIUM-LECANII .3. 23,24,25,26,27-PENTANORLANOST-8-EN-3-BETA,22-DIOL FROM VERTICILLIUM-LECANII
    GROVE, JF
    [J]. PHYTOCHEMISTRY, 1984, 23 (08) : 1721 - 1723
  • [10] KAHLOS K, 1986, PLANTA MED, P495, DOI 10.1055/s-2007-969266
123