SNX17 Facilitates Infection with Diverse Papillomavirus Types

被引：45

作者：

Bergant, Martina ^{[1
,2
]}

Banks, Lawrence ^{[1
]}

机构：

[1] Int Ctr Genet Engn & Biotechnol, I-34012 Trieste, Italy

[2] Univ Nova Gorica, Environm Res Lab, Nova Gorica, Slovenia

来源：

JOURNAL OF VIROLOGY | 2013年 / 87卷 / 02期

关键词：

MINOR CAPSID PROTEIN; L2; ENDOSOMES; TRAFFICKING; ENDOCYTOSIS; DOMAIN;

D O I：

10.1128/JVI.01991-12

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

Previous studies have shown that the human papillomavirus type 16 (HPV-16) L2 capsid protein plays an essential role in viral infection, in part through its interaction with sorting nexin 17 (SNX17). We now show that this interaction between L2 and SNX17 is conserved across multiple PV types. Furthermore, we demonstrate that SNX17 is essential for infection with all PV types analyzed, indicating an evolutionarily highly conserved virus entry mechanism.

引用

页码：1270 / 1273

页数：4

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