Development and in vitro evaluation of coated pellets containing chitosan to potential colonic drug delivery

被引：33

作者：

Ferrari, Priscileila Colerato ^{[1
]}

Souza, Fagner Magalhaes ^{[2
]}

Giorgetti, Leandro ^{[2
]}

Oliveira, Giselle Faria ^{[1
]}

Ferraz, Humberto Gomes ^{[2
]}

Chaud, Marco Vinicius ^{[3
]}

Evangelista, Raul Cesar ^{[1
]}

机构：

[1] Sao Paulo State Univ UNESP, Sch Pharmaceut Sci, Dept Drugs & Pharmaceut, Araraquara, SP, Brazil

[2] Univ Sao Paulo, Dept Pharm, Sch Pharmaceut Sci, Sao Paulo, Brazil

[3] Sorocaba Univ, Pharmaceut Sci Postgrad Program, Sorocaba, SP, Brazil

来源：

CARBOHYDRATE POLYMERS | 2013年 / 91卷 / 01期

关键词：

Pellets; Metronidazole; Colonic drug delivery; Chitosan; Enteric coating; Intestinal permeation; RELEASE; DISSOLUTION; ABSORPTION;

D O I：

10.1016/j.carbpol.2012.08.044

中图分类号：

O69 [应用化学];

学科分类号：

081704 ;

摘要：

In this work pellets containing chitosan for colonic drug delivery were developed. The influence of the polysaccharide in the pellets was evaluated by swelling, drug dissolution and intestinal permeation studies. Drug-loaded pellets containing chitosan as swellable polymer were coated with an inner layer of Kollicoat (R) SR 30 D and an outer layer of the enteric polymer Kollicoat (R) MAE 30 DP in a fluidized-bed apparatus. Metronidazole released from pellets was assessed using Bio-Dis dissolution method. Swelling, drug release and intestinal permeation were dependent on the chitosan and the coating composition. The drug release data fitted well with the Weibull equation, indicating that the drug release was controlled by diffusion, polymer relaxation and erosion occurring simultaneously. The film coating was found to be the main factor controlling the drug release and the chitosan controlling the drug intestinal permeation. Coated pellets containing chitosan show great potential as a system for drug delivery to the colon. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：244 / 252

页数：9

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