rTMS over bilateral inferior parietal cortex induces decrement of spatial sustained attention

被引:22
作者
Lee, Jeyeon [1 ]
Ku, Jeonghun [2 ]
Han, Kiwan [3 ]
Park, Jinsick [4 ,5 ]
Lee, Hyeongrae [6 ]
Kim, Kyung Ran [7 ]
Lee, Eun [7 ]
Husain, Masud [8 ,9 ]
Yoon, Kang Jun [10 ]
Kim, In Young [1 ]
Jang, Dong Pyo [1 ]
Kim, Sun I. [1 ,11 ]
机构
[1] Hanyang Univ, Dept Biomed Engn, Seoul 133791, South Korea
[2] Keimyung Univ, Dept Biomed Engn, Taegu, South Korea
[3] Yonsei Univ, Coll Med, Dept Rehabil & Assist Technol, Natl Rehabil Ctr,Res Inst, Seoul, South Korea
[4] Seoul Natl Univ Hosp, Dept Neuropsychiat, Seoul 110744, South Korea
[5] Seoul Natl Univ Hosp, Clin Res Inst, Seoul 110744, South Korea
[6] Seoul Natl Univ, Coll Med, MEG Ctr, Dept Neurosurg, Seoul, South Korea
[7] Yonsei Univ, Coll Med, Dept Psychiat, Seoul, South Korea
[8] UCL, Inst Neurol, London, England
[9] UCL, Inst Cognit Neurosci, London, England
[10] St Peters Hosp, Seoul, South Korea
[11] Osong Med Innovat Fdn, Med Device Dev Ctr, Chungbuk, South Korea
来源
FRONTIERS IN HUMAN NEUROSCIENCE | 2013年 / 7卷
基金
新加坡国家研究基金会;
关键词
sustained attention; vigilance; repeated transcranial magnetic stimulation; inferior parietal lobe; spatial attention; TRANSCRANIAL MAGNETIC STIMULATION; CONCURRENT TMS-FMRI; MOTOR CORTEX; VISUOSPATIAL ATTENTION; FRONTAL LESIONS; NEGLECT; TASK; FREQUENCY; DEFICITS; EXCITABILITY;
D O I
10.3389/fnhum.2013.00026
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Sustained attention is an essential brain function that enables a subject to maintain attention level over the time of a task. In previous work, the right inferior parietal lobe (IPL) has been reported as one of the main brain images related to sustained attention, however, the right lateralization of vigilance/sustained attention is unclear because information about the network for sustained attention is traditionally provided by neglect patients who typically have right brain damage. Here, we investigated sustained attention by applying a virtual lesion technique, transcranial magnetic stimulation (TMS), over the left and right superior parietal lobe (SPL) and IPL. We used two different types of visual sustained attention tasks: spatial (location based) and non-spatial (feature based). When the participants performed the spatial task, repetitive TMS (rTMS) over either the right or left IPL induced a significant decrement of sustained attention causing a progressive increment of errors and response time. In contrast, participants' performance was not changed by rTMS on the non-spatial task. Also omission errors (true negative) gradually increased with time on right and left IPL rTMS conditions, while commission errors (false positive) were relatively stable. These findings suggest that the maintenance of attention, especially in tasks regarding spatial location, is not uniquely lateralized to the right IPL, but may also involve participation of the left IPL.
引用
收藏
页数:8
相关论文
共 45 条
[1]   Changes in neuronal activation with increasing attention demand in healthy volunteers: An fMRI study [J].
Adler, CM ;
Sax, KW ;
Holland, SK ;
Schmithorst, V ;
Rosenberg, L ;
Strakowski, SM .
SYNAPSE, 2001, 42 (04) :266-272
[2]   Dorsal premotor cortex exerts state-dependent causal influences on activity in contralateral primary motor and dorsal premotor cortex [J].
Bestmann, Sven ;
Swayne, Orlando ;
Blankenburg, Felix ;
Ruff, Christian C. ;
Haggard, Patrick ;
Weiskopf, Nikolaus ;
Josephs, Oliver ;
Driver, Jon ;
Rothwell, John C. ;
Ward, Nick S. .
CEREBRAL CORTEX, 2008, 18 (06) :1281-1291
[3]   Studying the Role of Human Parietal Cortex in Visuospatial Attention with Concurrent TMS-fMRI [J].
Blankenburg, Felix ;
Ruff, Christian C. ;
Bestmann, Sven ;
Bjoertomt, Otto ;
Josephs, Oliver ;
Deichmann, Ralf ;
Driver, Jon .
CEREBRAL CORTEX, 2010, 20 (11) :2702-2711
[4]   Interhemispheric Effect of Parietal TMS on Somatosensory Response Confirmed Directly with Concurrent TMS-fMRI [J].
Blankenburg, Felix ;
Ruff, Christian C. ;
Bestmann, Sven ;
Bjoertomt, Otto ;
Eshel, Neir ;
Josephs, Oliver ;
Weiskopf, Nikolaus ;
Driver, Jon .
JOURNAL OF NEUROSCIENCE, 2008, 28 (49) :13202-13208
[5]   Neglect and extinction depend greatly on task demands: a review [J].
Bonato, Mario .
FRONTIERS IN HUMAN NEUROSCIENCE, 2012, 6
[6]   Increased attentional demands impair contralesional space awareness following stroke [J].
Bonato, Mario ;
Priftis, Konstantinos ;
Marenzi, Roberto ;
Umilta, Carlo ;
Zorzi, Marco .
NEUROPSYCHOLOGIA, 2010, 48 (13) :3934-3940
[7]   Visual and motor cortex excitability:: a transcranial magnetic stimulation study [J].
Boroojerdi, B ;
Meister, IG ;
Foltys, H ;
Sparing, R ;
Cohen, LG ;
Töpper, R .
CLINICAL NEUROPHYSIOLOGY, 2002, 113 (09) :1501-1504
[8]   Depression of motor cortex excitability by low-frequency transcranial magnetic stimulation [J].
Chen, R ;
Classen, J ;
Gerloff, C ;
Celnik, P ;
Wassermann, EM ;
Hallett, M ;
Cohen, LG .
NEUROLOGY, 1997, 48 (05) :1398-1403
[9]   Spatial Neglect and Attention Networks [J].
Corbetta, Maurizio ;
Shulman, Gordon L. .
ANNUAL REVIEW OF NEUROSCIENCE, VOL 34, 2011, 34 :569-599
[10]   Monitoring for target objects: activation of right frontal and parietal cortices with increasing time on task [J].
Coull, JT ;
Frackowiak, RSJ ;
Frith, CD .
NEUROPSYCHOLOGIA, 1998, 36 (12) :1325-1334