Emerging mediators of airway smooth muscle dysfunction in asthma

被引：29

作者：

Yeganeh, Behzad ^{[1
]}

Xia, Connie ^{[2
]}

Movassagh, Hesam ^{[3
]}

Koziol-White, Cynthia ^{[4
]}

Chang, Ying ^{[5
,6
]}

Al-Alwan, Laila ^{[5
,6
]}

Bourke, Jane E. ^{[2
]}

Oliver, Brian G. G. ^{[7
]}

机构：

[1] Univ Manitoba, Dept Physiol, Manitoba Inst Child Hlth, Winnipeg, MB, Canada

[2] Univ Melbourne, Dept Pharmacol, Melbourne, Vic 3010, Australia

[3] Univ Manitoba, Dept Immunol, Winnipeg, MB, Canada

[4] Univ Penn, Med Ctr, Pulm Allergy & Crit Care Div, Philadelphia, PA 19104 USA

[5] McGill Univ, Meakins Christie Labs, Dept Med, Montreal, PQ, Canada

[6] McGill Univ, Dept Med, Div Resp, Montreal, PQ, Canada

[7] Univ Sydney, Dept Pharmacol, Sydney, NSW 2006, Australia

来源：

PULMONARY PHARMACOLOGY & THERAPEUTICS | 2013年 / 26卷 / 01期

基金：

英国医学研究理事会;

关键词：

Asthma; Airway smooth muscle; NF-KAPPA-B; MAST-CELL; CXC-CHEMOKINES; HUMAN LUNG; NEUTROPHIL RECRUITMENT; ALTERED RESPONSIVENESS; INDUCED PROLIFERATION; AUTOCRINE ROLE; MESSENGER-RNA; GROWTH-FACTOR;

D O I：

10.1016/j.pupt.2012.06.011

中图分类号：

R9 [药学];

学科分类号：

1007 ;

摘要：

Phenotypic changes in airway smooth muscle are integral to the pathophysiological changes that constitute asthma namely inflammation, airway wall remodelling and bronchial hyperresponsiveness. In vitro and in vivo studies have shown that the proliferative, secretory and contractile functions of airway smooth muscle are dysfunctional in asthma. These functions can be modulated by various mediators whose levels are altered in asthma, derived from inflammatory cells or produced by airway smooth muscle itself. In this review, we describe the emerging roles of the CXC chemokines (GROs, IP-10), Th17-derived cytokines (IL-17, IL-22) and semaphorins, as well as the influence of viral infection on airway smooth muscle function, with a view to identifying new opportunities for therapeutic intervention in asthma. Crown Copyright (C) 2012 Published by Elsevier Ltd. All rights reserved.

引用

页码：105 / 111

页数：7

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