CD4 costimulation is not required in a novel LPS-enhanced model of myasthenia gravis

被引：7

作者：

Allman, Windy ^{[1
]}

Qi, Huibin ^{[1
]}

Saini, Shamsher S. ^{[1
]}

Li, Jing ^{[1
]}

Tuzun, Erdem ^{[1
]}

Christadoss, Premkumar ^{[1
]}

机构：

[1] Univ Texas Galveston, Med Branch, Dept Microbiol & Immunol, Galveston, TX 77555 USA

来源：

JOURNAL OF NEUROIMMUNOLOGY | 2012年 / 249卷 / 1-2期

关键词：

Myasthenia gravis; Experimental autoimmune myasthenia gravis; Autoimmunity; Lipopolysaccharide; CD4; ACETYLCHOLINE-RECEPTORS; AUTOIMMUNE-DISEASES; IMMUNE-RESPONSES; T-CELLS; MICE; COMPLEMENT; DIFFERENTIATION; INHIBITION; ANTIBODIES; INDUCTION;

D O I：

10.1016/j.jneuroim.2012.04.002

中图分类号：

R392 [医学免疫学]; Q939.91 [免疫学];

学科分类号：

100102 ;

摘要：

The potential of lipopolysaccharide (LPS) to induce antigen-specific B cell responses to acetylcholine receptor (AChR) in myasthenia gravis (MG) was evaluated in wild type (WT) and CD4-/- C57BL/6 mice. The WT mice immunized with AChR in LPS developed an MG-like disease (LPS-EAMG) similar to that induced by immunization with AChR in complete Freund's adjuvant (CFA-EAMG). CD4-/- mice were resistant to CFA-EAMG but susceptible to LPS-EAMG. LPS abrogated EAMG resistance in CD4-/- mice by increasing high-affinity anti-AChR IgG2b in sera and enhancing immune complex deposition in muscle. (C) 2012 Elsevier B.V. All rights reserved.

引用

页码：1 / 7

页数：7

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