Feasibility of in vivo intravascular photoacoustic imaging using integrated ultrasound and photoacoustic imaging catheter

被引：43

作者：

Karpiouk, Andrei B. ^{[1
]}

Wang, Bo ^{[1
]}

Amirian, James ^{[2
]}

Smalling, Richard W. ^{[2
]}

Emelianov, Stanislav Y. ^{[1
]}

机构：

[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA

[2] Univ Texas Hlth Sci Ctr, Div Cardiol, Houston, TX 77030 USA

来源：

JOURNAL OF BIOMEDICAL OPTICS | 2012年 / 17卷 / 09期

基金：

美国国家卫生研究院;

关键词：

in vivo; intravascular; photoacoustic imaging; ultrasound imaging; intravascular ultrasound/intravascular photoacoustic; stent; atherosclerosis; ATHEROSCLEROTIC PLAQUES; STENT RESTENOSIS; NM; SPECTROSCOPY; WAVELENGTH; PREDICTORS; MECHANISMS; BLOOD; LASER;

D O I：

10.1117/1.JBO.17.9.096008

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Pilot studies of in vivo combined intravascular ultrasound (IVUS) and intravascular photoacoustic (IVPA) imaging are reported. A recently introduced prototype of an integrated IVUS/IVPA imaging catheter consisting of a single-element ultrasound transducer and a light delivery system based on a single optical fiber was adapted and used for in vivo imaging of a coronary stent deployed in a rabbit's thoracic aorta in the presence of luminal blood. The results suggest that in vivo IVUS/IVPA imaging is feasible using the integrated IVUS/IVPA imaging catheter. The challenges of in vivo combined IVUS/IVPA imaging are discussed, and further improvements on the design of the catheter and the clinical imaging system are proposed. (C) 2012 Society of Photo-Optical Instrumentation Engineers (SPIE). [DOI: 10.1117/1.JBO.17.9.096008]

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