Reactivity of Persulfides Toward Strained Bicyclo[6.1.0]nonyne Derivatives: Relevance to Chemical Tagging of Proteins

被引：21

作者：

Galardon, Erwan ^{[1
]}

Padovani, Dominique ^{[1
]}

机构：

[1] Univ Paris 05, LCBPT, Sorbonne Paris Cite, CNRS,UMR 8601, F-75006 Paris, France

来源：

BIOCONJUGATE CHEMISTRY | 2015年 / 26卷 / 06期

关键词：

AZIDE-ALKYNE CYCLOADDITION; S-SULFHYDRATION; SULFANE SULFUR; SULFENIC ACID; SERUM-ALBUMIN; CHEMISTRY; ACTIVATION; REPAIR; DAMAGE; H2S;

D O I：

10.1021/acs.bioconjchem.5b00243

中图分类号：

Q5 [生物化学];

学科分类号：

071010 ; 081704 ;

摘要：

Persulfides are an emerging class of cysteine oxidative post-translational modification. They react with the bioconjugation reagents bicylo[6.1.0]nonynes (BCNs) to engender thioethers and/or disulfides. This new reactivity of BCNs with a biologically important redox-signaling species efficiently interferes with the recent usage of strained cycloalkynes to specifically trap protein sulfenic acids.

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页码：1013 / 1016

页数：4

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