共 25 条
Mitochondrial DNA and survival after sepsis: a prospective study
被引:139
作者:

Baudouin, SV
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Saunders, D
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Tiangyou, W
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Elson, JL
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Poynter, J
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Pyle, A
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Keers, S
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Turnbull, DM
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Howell, N
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Chinnery, PF
论文数: 0 引用数: 0
h-index: 0
机构: Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
机构:
[1] Newcastle Univ, Mitochondrial Res Grp, Sch Med, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[2] Newcastle Univ, Univ Dept Surg & Reprod Sci, Newcastle Upon Tyne NE1 7RU, Tyne & Wear, England
[3] Migenix Corp, San Diego, CA USA
来源:
基金:
英国惠康基金;
关键词:
D O I:
10.1016/S0140-6736(05)67890-7
中图分类号:
R5 [内科学];
学科分类号:
1002 ;
100201 ;
摘要:
Background Human genome evolution has been shaped by infectious disease. Although most genetic studies have focused on the immune system, recovery after sepsis is directly related to physiological reserve that is critically dependent on mitochondrial function. We investigated whether haplogroup H, the most common type of mitochondrial DNA (mtDNA) in Europe, contributes to the subtle genetic variation in survival after sepsis. Methods In a prospective study, we included 150 individuals who were sequentially admitted to the intensive care unit in a hospital in Newcastle upon Tyne, UK. After clinical data were obtained, patients underwent mtDNA haplotyping by analysis with PCR and restriction fragment length polymorphism. As endpoints, we used death during the 6-month period or survival at 6 months. Findings Follow-up was complete for all study participants, although the haplotype of two patients could not be reliably determined. On admission to the intensive care unit, the frequency of mtDNA haplogroup H in study patients did not differ between study patients admitted with severe sepsis and 542 age-matched controls from the northeast of England. MtDNA haplogroup H was a strong independent predictor of outcome during severe sepsis, conferring a 2.12-fold (95% CI 1.02-4.43) increased chance of survival at 180 days compared with individuals without the haplogroup H. Interpretation Although haplogroup H is the most recent addition to the group of European mtDNA, paradoxically it is also the most common. increased survival after sepsis provides one explanation for this observation. MtDNA haplotyping offers a new means of risk stratification of patients with severe infections, which suggests new avenues for therapeutic intervention.
引用
收藏
页码:2118 / 2121
页数:4
相关论文
共 25 条
[1]
The molecular dissection of mtDNA haplogroup H confirms that the Franco-Cantabrian glacial refuge was a major source for the European gene pool
[J].
Achilli, A
;
Rengo, C
;
Magri, C
;
Battaglia, V
;
Olivieri, A
;
Scozzari, R
;
Cruciani, F
;
Zeviani, M
;
Briem, E
;
Carelli, V
;
Moral, P
;
Dugoujon, JM
;
Roostalu, U
;
Loogväli, EL
;
Kivisild, T
;
Bandelt, HJ
;
Richards, M
;
Villems, R
;
Santachiara-Benerecetti, AS
;
Semino, O
;
Torroni, A
.
AMERICAN JOURNAL OF HUMAN GENETICS,
2004, 75 (05)
:910-918

Achilli, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Rengo, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Magri, C
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Battaglia, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Olivieri, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Scozzari, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Cruciani, F
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Zeviani, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Briem, E
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Carelli, V
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Moral, P
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Dugoujon, JM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Roostalu, U
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Loogväli, EL
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Kivisild, T
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Bandelt, HJ
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Richards, M
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Villems, R
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Santachiara-Benerecetti, AS
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Semino, O
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy

Torroni, A
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pavia, Dipartimento Genet & Microbiol, I-27100 Pavia, Italy
[2]
Epidemiology of severe sepsis in the United States: Analysis of incidence, outcome, and associated costs of care
[J].
Angus, DC
;
Linde-Zwirble, WT
;
Lidicker, J
;
Clermont, G
;
Carcillo, J
;
Pinsky, MR
.
CRITICAL CARE MEDICINE,
2001, 29 (07)
:1303-1310

Angus, DC
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA

Linde-Zwirble, WT
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA

Lidicker, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA

Clermont, G
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA

Carcillo, J
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA

Pinsky, MR
论文数: 0 引用数: 0
h-index: 0
机构: Univ Pittsburgh, Dept Anesthesiol & Crit Care Med, Crit Care Med Div, Pittsburgh, PA 15213 USA
[3]
Association between mitochondrial dysfunction and severity and outcome of septic shock
[J].
Brealey, D
;
Brand, M
;
Hargreaves, I
;
Heales, S
;
Land, J
;
Smolenski, R
;
Davies, NA
;
Cooper, CE
;
Singer, M
.
LANCET,
2002, 360 (9328)
:219-223

Brealey, D
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Brand, M
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Hargreaves, I
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Heales, S
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Land, J
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Smolenski, R
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Davies, NA
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Cooper, CE
论文数: 0 引用数: 0
h-index: 0
机构: UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England

Singer, M
论文数: 0 引用数: 0
h-index: 0
机构:
UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England UCL, Wolfson Inst Biomed Res, Bloomsbury Inst Intens Care Med, London W1T 3AA, England
[4]
Mitochondrial DNA haplogroups and susceptibility to AD and dementia with Lewy bodies
[J].
Chinnery, PF
;
Taylor, GA
;
Howell, N
;
Andrews, RM
;
Morris, CM
;
Taylor, RW
;
McKeith, IG
;
Perry, RH
;
Edwardson, JA
;
Turnbull, DM
.
NEUROLOGY,
2000, 55 (02)
:302-304

Chinnery, PF
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Taylor, GA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Howell, N
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Andrews, RM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Morris, CM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Taylor, RW
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

McKeith, IG
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Perry, RH
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Edwardson, JA
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England

Turnbull, DM
论文数: 0 引用数: 0
h-index: 0
机构: Univ Newcastle Upon Tyne, Dept Neurol, Med Sch Newcastle Upon Tyne, Newcastle Upon Tyne NE2 4HH, Tyne & Wear, England
[5]
Mechanisms of disease: Mitochondrial respiratory-chain diseases
[J].
DiMauro, S
;
Schon, EA
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 348 (26)
:2656-2668

DiMauro, S
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA

Schon, EA
论文数: 0 引用数: 0
h-index: 0
机构: Columbia Univ Coll Phys & Surg, Dept Neurol, New York, NY 10032 USA
[6]
Cytopathic hypoxia - Mitochondrial dysfunction as mechanism contributing to organ dysfunction in sepsis
[J].
Fink, MP
.
CRITICAL CARE CLINICS,
2001, 17 (01)
:219-+

Fink, MP
论文数: 0 引用数: 0
h-index: 0
机构:
Univ Pittsburgh, Med Ctr, Sch Med, Div Crit Care Med, Pittsburgh, PA 15261 USA Univ Pittsburgh, Med Ctr, Sch Med, Div Crit Care Med, Pittsburgh, PA 15261 USA
[7]
Mitochondrial DNA haplogroup K is associated with a lower risk of Parkinson's disease in Italians
[J].
Ghezzi, D
;
Marelli, C
;
Achilli, A
;
Goldwurm, S
;
Pezzoli, G
;
Barone, P
;
Pellecchia, MT
;
Stanzione, P
;
Brusa, L
;
Bentivoglio, AR
;
Bonuccelli, U
;
Petrozzi, L
;
Abbruzzese, G
;
Marchese, R
;
Cortelli, P
;
Grimaldi, D
;
Martinelli, P
;
Ferrarese, C
;
Garavaglia, B
;
Sangiorgi, S
;
Carelli, V
;
Torroni, A
;
Albanese, A
;
Zeviani, M
.
EUROPEAN JOURNAL OF HUMAN GENETICS,
2005, 13 (06)
:748-752

Ghezzi, D
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Marelli, C
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Achilli, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Goldwurm, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Pezzoli, G
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Barone, P
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Pellecchia, MT
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Stanzione, P
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Brusa, L
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Bentivoglio, AR
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Bonuccelli, U
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Petrozzi, L
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Abbruzzese, G
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Marchese, R
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Cortelli, P
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Grimaldi, D
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Martinelli, P
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Ferrarese, C
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Garavaglia, B
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Sangiorgi, S
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Carelli, V
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Torroni, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Albanese, A
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy

Zeviani, M
论文数: 0 引用数: 0
h-index: 0
机构: Natl Neurol Inst Carlo Besta, Unit Mol Neurogenet, I-20126 Milan, Italy
[8]
SIGNIFICANCE OF MITOCHONDRIAL ENHANCEMENT IN HEPATIC ENERGY-METABOLISM IN RELATION TO ALTERATIONS IN HEMODYNAMICS IN SEPTIC PIGS WITH SEVERE PERITONITIS
[J].
HIRAI, F
;
AOYAMA, H
;
OHTOSHI, M
;
KAWASHIMA, S
;
OZAWA, K
;
TOBE, T
.
EUROPEAN SURGICAL RESEARCH,
1984, 16 (03)
:148-155

HIRAI, F
论文数: 0 引用数: 0
h-index: 0

AOYAMA, H
论文数: 0 引用数: 0
h-index: 0

OHTOSHI, M
论文数: 0 引用数: 0
h-index: 0

KAWASHIMA, S
论文数: 0 引用数: 0
h-index: 0

OZAWA, K
论文数: 0 引用数: 0
h-index: 0

TOBE, T
论文数: 0 引用数: 0
h-index: 0
[9]
Genetic polymorphisms in sepsis and septic shock - Role in prognosis and potential for therapy
[J].
Holmes, CL
;
Russell, JA
;
Walley, KR
.
CHEST,
2003, 124 (03)
:1103-1115

Holmes, CL
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada

Russell, JA
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada

Walley, KR
论文数: 0 引用数: 0
h-index: 0
机构:
Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada Univ British Columbia, McDonald Res Labs, iCAPTURE Ctr, Providence Hlth Care, Vancouver, BC V6Z 1Y6, Canada
[10]
Medical progress: The pathophysiology and treatment of sepsis.
[J].
Hotchkiss, RS
;
Karl, IE
.
NEW ENGLAND JOURNAL OF MEDICINE,
2003, 348 (02)
:138-150

Hotchkiss, RS
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA

Karl, IE
论文数: 0 引用数: 0
h-index: 0
机构: Washington Univ, Sch Med, Dept Anesthesiol, St Louis, MO 63110 USA