CholesteroNitrones for Stroke

被引：27

作者：

Ayuso, Maria I. ^{[1
]}

Chioua, Mourad ^{[2
]}

Martinez-Alonso, Emma ^{[1
]}

Soriano, Elena ^{[3
]}

Montaner, Joan ^{[4
,5
]}

Masjuan, Jaime ^{[6
]}

Hadjipavlou-Litina, Dimitra J. ^{[7
]}

Marco-Contelles, Jose ^{[2
]}

Alcazar, Alberto ^{[1
]}

机构：

[1] Hosp Ramon & Cajal, IRYCIS, Dept Invest, E-28034 Madrid, Spain

[2] CSIC, Inst Organ Chem, Lab Med Chem, Madrid 29006, Spain

[3] CSIC, Inst Quim Organ Gen, SEPCO, E-28006 Madrid, Spain

[4] Univ Autonoma Barcelona, Inst Recerca Vall dHebron, Barcelona 08035, Spain

[5] Hosp Valle De Hebron, Barcelona 08035, Spain

[6] Hosp Ramon & Cajal, Dept Neurol, IRYCIS, E-28034 Madrid, Spain

[7] Aristotle Univ Thessaloniki, Dept Pharmaceut Chem, Fac Hlth Sci, Thessaloniki 54124, Greece

来源：

JOURNAL OF MEDICINAL CHEMISTRY | 2015年 / 58卷 / 16期

关键词：

CEREBRAL-ISCHEMIA; BRAIN-INJURY; NITRONES; NXY-059; NEUROPROTECTION; ANTIOXIDANTS; THERAPEUTICS; BARRIER; AGENTS; PBN;

D O I：

10.1021/acs.jmedchem.5b00755

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

This study describes CholesteroNitrone 2 as an antioxidant and neuroprotective agent against ischemic injury. Neuroprotection was assessed using in vitro and in vivo experimental ischemia models. The compound significantly increased cell viability, induced neuroprotection following ischemic reperfusion, and decreased neurological deficit scores in treated animals, supporting the next preclinical studies as a potential agent for the treatment of stroke.

引用

页码：6704 / 6709

页数：6

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