In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae

被引：17

作者：

Chotikanatis, Kobkui ^{[1
]}

Kohlhoff, Stephan A. ^{[1
]}

Hammerschlag, Margaret R. ^{[1
]}

机构：

[1] Suny Downstate Med Ctr, Dept Pediat, Div Infect Dis, Brooklyn, NY 11203 USA

来源：

ANTIMICROBIAL AGENTS AND CHEMOTHERAPY | 2014年 / 58卷 / 03期

关键词：

NON-FLUORINATED QUINOLONE; STREPTOCOCCUS-PNEUMONIAE; TG-873870; SAFETY;

D O I：

10.1128/AAC.02263-13

中图分类号：

Q93 [微生物学];

学科分类号：

071005 ; 100705 ;

摘要：

The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC(90)s) were 0.06 mu g/ml (range, 0.03 to 0.13 mu g/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC(90)s) were 0.06 mu g/ml for C. trachomatis (range, 0.03 to 0.125 mu g/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 mu g/ml).

引用

页码：1800 / 1801

页数：2

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