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In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae
被引:17
作者:
Chotikanatis, Kobkui
[1
]
Kohlhoff, Stephan A.
[1
]
Hammerschlag, Margaret R.
[1
]
机构:
[1] Suny Downstate Med Ctr, Dept Pediat, Div Infect Dis, Brooklyn, NY 11203 USA
关键词:
NON-FLUORINATED QUINOLONE;
STREPTOCOCCUS-PNEUMONIAE;
TG-873870;
SAFETY;
D O I:
10.1128/AAC.02263-13
中图分类号:
Q93 [微生物学];
学科分类号:
071005 ;
100705 ;
摘要:
The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC(90)s) were 0.06 mu g/ml (range, 0.03 to 0.13 mu g/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC(90)s) were 0.06 mu g/ml for C. trachomatis (range, 0.03 to 0.125 mu g/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 mu g/ml).
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页码:1800 / 1801
页数:2
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