In Vitro Activity of Nemonoxacin, a Novel Nonfluorinated Quinolone Antibiotic, against Chlamydia trachomatis and Chlamydia pneumoniae

被引:17
作者
Chotikanatis, Kobkui [1 ]
Kohlhoff, Stephan A. [1 ]
Hammerschlag, Margaret R. [1 ]
机构
[1] Suny Downstate Med Ctr, Dept Pediat, Div Infect Dis, Brooklyn, NY 11203 USA
关键词
NON-FLUORINATED QUINOLONE; STREPTOCOCCUS-PNEUMONIAE; TG-873870; SAFETY;
D O I
10.1128/AAC.02263-13
中图分类号
Q93 [微生物学];
学科分类号
071005 ; 100705 ;
摘要
The in vitro activities of nemonoxacin, levofloxacin, azithromycin, and doxycycline were tested against 10 isolates each of Chlamydia trachomatis and Chlamydia pneumoniae. The MICs at which 90% of the isolates of both C. trachomatis and C. pneumoniae were inhibited (MIC(90)s) were 0.06 mu g/ml (range, 0.03 to 0.13 mu g/ml). The minimal bactericidal concentrations at which 90% of the isolates were killed by nemonoxacin (MBC(90)s) were 0.06 mu g/ml for C. trachomatis (range, 0.03 to 0.125 mu g/ml) and 0.25 for C. pneumoniae (range, 0.015 to 0.5 mu g/ml).
引用
收藏
页码:1800 / 1801
页数:2
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