Aminoglycoside-associated severe renal failure in patients with multiple myeloma treated with thalidomide

被引：14

作者：

Montagut, C ^{[1
]}

Bosch, F ^{[1
]}

Villela, L ^{[1
]}

Rosiñol, L ^{[1
]}

Bladé, J ^{[1
]}

机构：

[1] Univ Barcelona, Hosp Clin, IDIBAPS, ICMHO,Dept Hematol, E-08036 Barcelona, Spain

来源：

LEUKEMIA & LYMPHOMA | 2004年 / 45卷 / 08期

关键词：

multiple myeloma; thalidomide; aminoglycoside; renal failure;

D O I：

10.1080/10428190310001638841

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

Thalidomide has been proved to play an important role in rescue treatment of patients with refractory/relapsed multiple myeloma (MM). However, thalidomide therapy is associated with numerous side effects, mainly somnolence, constipation, fatigue or peripheral neuropathy. We report three patients diagnosed with MM and treated with thalidomide as salvage therapy who developed severe renal failure when they received aminoglycoside antibiotics. This observation suggests that thalidomide can potentiate nephrotoxicity of aminoglycoside antibiotics in patients with MM.

引用

页码：1711 / 1712

页数：2

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