Epigenetic programming of obesity and diabetes by in utero exposure to gestational diabetes mellitus

被引：93
|
作者：
Ruchat, Stephanie-May [1 ,2 ,3 ]
Hivert, Marie-France [4 ]
Bouchard, Luigi [1 ,2 ,3 ]
机构：
[1] Univ Sherbrooke, Dept Biochem, Sherbrooke, PQ J1K 2R1, Canada
[2] Chicoutimi Hosp, ECOGENE 21, Saguenay, PQ, Canada
[3] Chicoutimi Hosp, Lipid Clin, Saguenay, PQ, Canada
[4] Univ Sherbrooke, Dept Med, Sherbrooke, PQ J1K 2R1, Canada
来源：
NUTRITION REVIEWS | 2013年 / 71卷
关键词：
altered intrauterine environment; diabetes; epigenetic modifications; fetal metabolic programming; gestational diabetes; obesity; DNA METHYLATION; BIRTH-WEIGHT; INTRAUTERINE EXPOSURE; GENE-EXPRESSION; GLUCOCORTICOID-RECEPTOR; PROMOTER METHYLATION; CARDIOVASCULAR RISK; ASSOCIATION; ADIPONECTIN; LEPTIN;
D O I：
10.1111/nure.12057
中图分类号：
R15 [营养卫生、食品卫生]; TS201 [基础科学];
学科分类号：
100403 ;
摘要：
It is now well accepted that offspring exposed to maternal undernutrition, obesity, or gestational diabetes mellitus have an increased risk for chronic diseases later in life, supporting the theory of the early origins of chronic diseases. However, the molecular mechanisms through which the exposure to an altered in utero environment translates into the development of chronic diseases are not yet well understood. Recently reported promising results help to resolve this issue. They suggest that epigenetic modifications are a potential mechanism for fetal metabolic programming. This review provides an overview of the relationship between the exposure to an altered intrauterine environment and fetal metabolic programming, focusing on gestational diabetes mellitus and epigenetic variations at adipokine candidate genes. (C) 2013 International Life Sciences Institute
引用
收藏
页码：S88 / S94
页数：7
相关论文
共 50 条
  • [21] Prepregnancy obesity and the risk of gestational diabetes mellitus
    Anussara Kongubol
    Vorapong Phupong
    BMC Pregnancy and Childbirth, 11
  • [22] Gestational diabetes mellitus after gestational diabetes mellitus
    Giuliani, C.
    Bitterman, O.
    Festa, C.
    Rozzi, V.
    Bianchi, P.
    Mattei, L.
    Bongiovanni, M.
    Toscano, V.
    Napoli, A.
    DIABETOLOGIA, 2013, 56 : S511 - S511
  • [23] Gestational diabetes mellitus, epigenetic age and offspring metabolism
    Kim, Catherine
    Harrall, Kylie K.
    Glueck, Deborah H.
    Needham, Belinda L.
    Dabelea, Dana
    DIABETIC MEDICINE, 2022, 39 (11)
  • [24] Genetic and Epigenetic Factors in Gestational Diabetes Mellitus Pathology
    Ustianowski, Lukasz
    Udzik, Jakub
    Szostak, Joanna
    Goracy, Anna
    Ustianowska, Klaudia
    Pawlik, Andrzej
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2023, 24 (23)
  • [25] Epigenetic Modifications Associated with Exposure to Endocrine Disrupting Chemicals in Patients with Gestational Diabetes Mellitus
    Kunysz, Mateusz
    Mora-Janiszewska, Olimpia
    Darmochwal-Kolarz, Dorota
    INTERNATIONAL JOURNAL OF MOLECULAR SCIENCES, 2021, 22 (09)
  • [26] Noise exposure and the risk of gestational diabetes mellitus
    Min, J.
    EUROPEAN JOURNAL OF PUBLIC HEALTH, 2016, 26 : 338 - 338
  • [27] Minireview: Epigenetic Programming of Diabetes and Obesity: Animal Models
    Seki, Yoshinori
    Williams, Lyda
    Vuguin, Patricia M.
    Charron, Maureen J.
    ENDOCRINOLOGY, 2012, 153 (03) : 1031 - 1038
  • [28] Prediction of gestational diabetes mellitus by different obesity indices
    Zhimin Song
    Yan Cheng
    Tingting Li
    Yongfang Fan
    Qingying Zhang
    Haidong Cheng
    BMC Pregnancy and Childbirth, 22
  • [29] Association of obesity and insulin resistance to gestational diabetes mellitus
    Thilak, Swathi
    Rajendra, Aishwarya
    Ganesh, Veluri
    BIOINFORMATION, 2023, 19 (02) : 211 - 214
  • [30] Percentage of Gestational Diabetes Mellitus Attributable to Overweight and Obesity
    Kim, Shin Y.
    England, Lucinda
    Wilson, Hoyt G.
    Bish, Connie
    Satten, Glen A.
    Dietz, Patricia
    AMERICAN JOURNAL OF PUBLIC HEALTH, 2010, 100 (06) : 1047 - 1052
12345