Identification of the true human orthologue of the mouse Zp1 gene:: evidence for greater complexity in the mammalian zona pellucida?

被引：89
作者：
Hughes, DC [1 ]
Barratt, CLR
机构：
[1] Birmingham Womens Hosp, Reprod Biol & Genet Grp, Assisted Concept Unit, Birmingham B15 2TG, W Midlands, England
[2] Univ Birmingham, Dept Med, Wolfson Labs, Birmingham, W Midlands, England
来源：
BIOCHIMICA ET BIOPHYSICA ACTA-GENE STRUCTURE AND EXPRESSION | 1999年 / 1447卷 / 2-3期
关键词：
oocyte; zona pellucida; ZP1; ZP2; ZP3; ZPB;
D O I：
10.1016/S0167-4781(99)00181-5
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
The mammalian zona pellucida is a mixture of glycoproteins, believed to be encoded by three distinct genes, ZP1/ZPB, ZP2/ZPA, and ZP3/ZPC. We have now determined that the true human orthologue of the mouse Zp1 gene is not ZPB, but that there is a distinct human ZP1 gene. Comparison of the human ZP1 and murine Zp1 genes indicates significant conservation of nucleotide and amino acid sequences, of intron-exon size and organisation, and of regulatory sequences. In addition, the mouse and human ZP1 genes are in a region of conserved synteny between human chromosome 11 and mouse chromosome 19. (C) 1999 Elsevier Science B.V. All rights reserved.
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收藏
页码：303 / 306
页数：4
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