Gammadelta T Cells: Innately Adaptive Immune Cells?

被引：54
作者：
Ferreira, Leonardo M. R. [1 ,2 ]
机构：
[1] Harvard Univ, Dept Mol & Cellular Biol, Cambridge, MA 02138 USA
[2] Harvard Univ, Dept Stem Cell & Regenerat Biol, Cambridge, MA 02138 USA
来源：
INTERNATIONAL REVIEWS OF IMMUNOLOGY | 2013年 / 32卷 / 03期
关键词：
ligand diversity; T cell development; TCR structure; tissue-specific T cells; gamma delta T cell; CLASS-I MOLECULES; PROFESSIONAL ANTIGEN-PRESENTATION; PRENYL PYROPHOSPHATE ANTIGENS; PROTEIN-TYROSINE KINASE; RECEPTOR ALPHA-CHAINS; NATURAL-KILLER-CELLS; TCR SIGNAL STRENGTH; DELTA-CELLS; LYMPHOCYTES BEARING; PERIPHERAL-BLOOD;
D O I：
10.3109/08830185.2013.783831
中图分类号：
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号：
100102 ;
摘要：
T cells employ a cell surface heterodimeric molecule, the T cell receptor (TCR), to recognize specific antigens (Ags) presented by major histocompatibility complex (MHC) molecules and carry out adaptive immune responses. Most T cells possess a TCR with an alpha and a beta chain. However, a TCR constituted by a gamma and a delta chain has been described, defining a novel subset of T cells. gamma delta TCRs specific for a wide variety of ligands, including bacterial phosphoantigens, nonclassical MHC-I molecules and unprocessed proteins, have been found, greatly expanding the horizons of T cell immune recognition. This review aims to provide background in. d T cell history and function in mouse and man, as well as to provide a critical view of some of the latest developments on this still enigmatic class of immune cells.
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收藏
页码：223 / 248
页数：26
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