Not all CD4+ memory T cells are long lived

被引:37
作者
Robertson, Jennifer M.
MacLeod, Megan
Marsden, Vanessa S.
Kappler, John W.
Marrack, Philippa
机构
[1] Natl Jewish Ctr Immunol & Resp Med, Integrated Dept Immunol, Howard Hughes Med Inst, Denver, CO 80206 USA
[2] UCDHSC, Denver, CO USA
关键词
D O I
10.1111/j.0105-2896.2006.00383.x
中图分类号
R392 [医学免疫学]; Q939.91 [免疫学];
学科分类号
100102 ;
摘要
Memory T cells are thought to have several properties that distinguish them from their naive precursors. They are found in parts of the body that rarely house naive cells, they respond to antigen with faster proliferation and more rapid progression to effector function, they are less sensitive to the absence of their selecting major histocompatibility complex (MHC), and, above all, they are long lived. Here we show that this last property may not be universal. Some CD4(+) T cells that have surface proteins characteristic of memory cells have the same half-life in vivo as naive cells. The description of these cells as memory cells therefore depends on our definition of the word 'memory'.
引用
收藏
页码:49 / 57
页数:9
相关论文
共 77 条
[1]   Long-lived poxvirus immunity, robust CD4 help, and better persistence of CD4 than CD8 T cells [J].
Amara, RR ;
Nigam, P ;
Sharma, S ;
Liu, J ;
Bostik, V .
JOURNAL OF VIROLOGY, 2004, 78 (08) :3811-3816
[2]  
ANDERSEN P, 1995, J IMMUNOL, V154, P3359
[3]  
ARANEO BA, 1976, J IMMUNOL, V117, P1233
[4]   CD4+CD25+ regulatory T cells control Leishmania major persistence and immunity [J].
Belkaid, Y ;
Piccirillo, CA ;
Mendez, S ;
Shevach, EM ;
Sacks, DL .
NATURE, 2002, 420 (6915) :502-507
[5]   INTERCONVERSION OF CD45R SUBSETS OF CD4 T-CELLS INVIVO [J].
BELL, EB ;
SPARSHOTT, SM .
NATURE, 1990, 348 (6297) :163-166
[6]   FUNCTIONAL SUBSETS OF T-CELLS DEFINED BY ISOFORMS OF CD45 [J].
BEVERLEY, PCL ;
DASER, A ;
MICHIE, CA ;
WALLACE, DL .
BIOCHEMICAL SOCIETY TRANSACTIONS, 1992, 20 (01) :184-187
[7]   HUMAN T-CELL SUBSETS [J].
BEVERLEY, PCL .
IMMUNOLOGY LETTERS, 1987, 14 (04) :263-267
[8]   DEFECTIVE MAJOR HISTOCOMPATIBILITY COMPLEX CLASS-II ASSEMBLY, TRANSPORT, PEPTIDE ACQUISITION, AND CD4+ T-CELL SELECTION IN MICE LACKING INVARIANT CHAIN EXPRESSION [J].
BIKOFF, EK ;
HUANG, LY ;
EPISKOPOU, V ;
VANMEERWIJK, J ;
GERMAIN, RN ;
ROBERTSON, EJ .
JOURNAL OF EXPERIMENTAL MEDICINE, 1993, 177 (06) :1699-1712
[9]   IL-7: maintaining T-cell memory and achieving homeostasis [J].
Bradley, LM ;
Haynes, L ;
Swain, SL .
TRENDS IN IMMUNOLOGY, 2005, 26 (03) :172-176
[10]   Lymphocyte migration into tissue: The paradigm derived from CD4 subsets [J].
Bradley, LM ;
Watson, SR .
CURRENT OPINION IN IMMUNOLOGY, 1996, 8 (03) :312-320