Identifying high-risk patients with natural killer/T-cell lymphoma undergoing autologous stem cell transplantation

被引：2

作者：

Bai, Bing ^{[1
,2
,3
]}

Gao, Yan ^{[1
,2
,3
]}

Wang, Xiao-Xiao ^{[1
,2
,3
]}

He, Hai-Xia ^{[1
,2
,3
]}

Ping, Li-Qin ^{[1
,2
,3
]}

Li, Peng-Fei ^{[1
,2
,3
]}

Huang, Cheng ^{[1
,2
,3
]}

Cai, Qi-Chun ^{[4
]}

Huang, Hui-Qiang ^{[1
,2
,3
]}

机构：

[1] Sun Yat Sen Univ, Dept Med Oncol, Canc Ctr, 651 Dongfeng East Rd, Guangzhou 510060, Peoples R China

[2] State Key Lab Oncol South China, Guangzhou, Peoples R China

[3] Collaborat Innovat Ctr Canc Med, Guangzhou, Peoples R China

[4] Guangdong Clifford Hosp, Dept Oncol, Guangzhou, Peoples R China

来源：

LEUKEMIA & LYMPHOMA | 2020年 / 61卷 / 14期

关键词：

Autologous stem cell transplantation; Epstein-Barr virus; high risk; natural killer; T-cell lymphoma; testis involvement; NASAL TYPE; CONCURRENT CHEMORADIOTHERAPY; (NK)/T-CELL LYMPHOMA; SMILE CHEMOTHERAPY; RESPONSE CRITERIA; L-ASPARAGINASE; PHASE-II; EBV-DNA; OUTCOMES; MULTICENTER;

D O I：

10.1080/10428194.2020.1808203

中图分类号：

R73 [肿瘤学];

学科分类号：

100214 ;

摘要：

At present, autologous stem cell transplantation (ASCT) is considered as an optional consolidation therapy for natural killer/T-cell lymphoma (NKTCL). However, the high-risk patients undergoing ASCT are not clear enough. In this study, 56 patients with advanced staged or relapsed/refractory (R/R) NKTCL undergoing ASCT were reviewed. All patients achieved clinical complete response (CR) before ASCT. The median follow-up time was 36 months (range, 3-192 months). The three-year overall survival (OS) and three-year progression-free survival (PFS) were 70.2% and 56.5%, respectively. The independent prognostic factors for OS included prior testis involvement and pre-ASCT EBV-DNA. Patients without prior testis involvement and negative pre-ASCT EBV-DNA (group A) had better three-year OS (86.3% vs. 47.6%,p < .001) than the rest patients (group B). In conclusion, our study suggests that testis involvement and elevated EBV-DNA might be strong adverse prognostic factors for NKTCL. Patients without the above risk factors are more likely to benefit from ASCT.

引用

页码：3404 / 3411

页数：8

共 32 条

[1] Comparison of Survival in Patients with T Cell Lymphoma after Autologous and Allogeneic Stem Cell Transplantation as a Frontline Strategy or in Relapsed Disease [J].

Beitinjaneh, Amer ;

Saliba, Rima M. ;

Medeiros, L. Jeffrey ;

Turturro, Francesco ;

Rondon, Gabriela ;

Korbling, Martin ;

Fayad, Luis ;

Fanale, Michelle A. ;

Alousi, Amin M. ;

Anderlini, Paolo ;

Betul, Oran ;

Popat, Uday R. ;

Pro, Barbara ;

Khouri, Issa F. .

BIOLOGY OF BLOOD AND MARROW TRANSPLANTATION, 2015, 21 (05) :855-859

[2] Management of Advanced and Relapsed/Refractory Extranodal Natural Killer T-Cell Lymphoma: An Analysis of Stem Cell Transplantation and Chemotherapy Outcomes [J].

Brammer, Jonathan E. ;

Chihara, Dai ;

Poon, L. Michelle ;

Caimi, Paolo ;

de Lima, Marcos ;

Ledesma, Celina ;

Rondon, Gabriela ;

Ciurea, Stefan O. ;

Nieto, Yago ;

Fanale, Michelle ;

Dabaja, Bouthaina ;

Maziarz, Richard T. ;

Champlin, Richard E. ;

Hosing, Chitra ;

Oki, Yasuhiro .

CLINICAL LYMPHOMA MYELOMA & LEUKEMIA, 2018, 18 (01) :E41-E50

[3] Report of an international workshop to standardize response criteria for non-Hodgkin's lymphomas [J].

Cheson, BD ;

Horning, SJ ;

Coiffier, B ;

Shipp, MA ;

Fisher, RI ;

Connors, JM ;

Lister, TA ;

Vose, J ;

Grillo-López, A ;

Hagenbeek, A ;

Cabanillas, F ;

Klippensten, D ;

Hiddemann, W ;

Castellino, R ;

Harris, NL ;

Armitage, JO ;

Carter, W ;

Hoppe, R ;

Canellos, GP .

JOURNAL OF CLINICAL ONCOLOGY, 1999, 17 (04) :1244-1253

[4] Revised response criteria for malignant lymphoma [J].

Cheson, Bruce D. ;

Pfistner, Beate ;

Juweid, Malik E. ;

Gascoyne, Randy D. ;

Specht, Lena ;

Horning, Sandra J. ;

Coiffier, Bertrand ;

Fisher, Richard I. ;

Hagenbeek, Anton ;

Zucca, Emanuele ;

Rosen, Steven T. ;

Stroobants, Sigrid ;

Lister, T. Andrew ;

Hoppe, Richard T. ;

Dreyling, Martin ;

Tobinai, Kensei ;

Vose, Julie M. ;

Connors, Joseph M. ;

Federico, Massimo ;

Diehl, Volker .

JOURNAL OF CLINICAL ONCOLOGY, 2007, 25 (05) :579-586

[5] Recommendations for Initial Evaluation, Staging, and Response Assessment of Hodgkin and Non-Hodgkin Lymphoma: The Lugano Classification [J].

Cheson, Bruce D. ;

Fisher, Richard I. ;

Barrington, Sally F. ;

Cavalli, Franco ;

Schwartz, Lawrence H. ;

Zucca, Emanuele ;

Lister, T. Andrew .

JOURNAL OF CLINICAL ONCOLOGY, 2014, 32 (27) :3059-+

[6] Allogeneic hematopoietic stem cell transplantation for advanced extranodal natural killer/T-cell lymphoma, nasal type [J].

Ennishi, Daisuke ;

Maeda, Yoshinobu ;

Fujii, Nobuharu ;

Kondo, Eisei ;

Shinagawa, Katsuji ;

Ikeda, Kazuma ;

Ichimura, Koichi ;

Yoshino, Tadashi ;

Tanimoto, Mitsune .

LEUKEMIA & LYMPHOMA, 2011, 52 (07) :1255-1261

[7] HLH-2004: Diagnostic and therapeutic guidelines for hemophagocytic lymphohistiocytosis [J].

Henter, Jan-Inge ;

Horne, AnnaCarin ;

Arico, Maurizio ;

Egeler, R. Maarten ;

Filipovich, Alexandra H. ;

Imashuku, Shinsaku ;

Ladisch, Stephan ;

McClain, Ken ;

Webb, David ;

Winiarski, Jacek ;

Janka, Gritta .

PEDIATRIC BLOOD & CANCER, 2007, 48 (02) :124-131

[8] Multicenter study of comparative outcomes of hematopoietic stem cell transplant for peripheral T cell lymphoma and natural killer/T-cell lymphoma [J].

Hwang, William Y. K. ;

Koh, Liang Piu ;

Lim, Soon-Thye ;

Linn, Yeh Ching ;

Loh, Yvonne S. ;

Koh, Mickey B. C. ;

Diong, Colin Phipps ;

Lee, Jing Jing ;

Zhang, Xue Hui ;

Rajgor, Dimple ;

Gandhi, Mihir ;

Shah, Anand ;

Goh, Yeow Tee .

LEUKEMIA & LYMPHOMA, 2011, 52 (07) :1382-1386

[9] Successful treatment of extranodal natural killer/T-cell lymphoma, nasal type, complicated by severe hemophagocytic syndrome, with dexamethasone, methotrexate, ifosfamide, L-asparaginase, and etoposide chemotherapy followed by autologous stem cell transplant [J].

Inoue, Daichi ;

Nagai, Yuya ;

Takiuchi, Yoko ;

Nagano, Seiji ;

Arima, Hiroshi ;

Kimura, Takaharu ;

Shimoji, Sonoko ;

Mori, Minako ;

Togami, Katsuhiro ;

Tabata, Sumie ;

Yanagita, Soshi ;

Matsushita, Akiko ;

Nagai, Kenichi ;

Maruoka, Hayato ;

Imai, Yukihiro ;

Suzuki, Ritsuro ;

Takahashi, Takayuki .

LEUKEMIA & LYMPHOMA, 2010, 51 (04) :720-723

[10] Pretreatment EBV-DNA Copy Number Is Predictive of Response and Toxicities to SMILE Chemotherapy for Extranodal NK/T-cell Lymphoma, Nasal Type [J].

Ito, Yoshinori ;

Kimura, Hiroshi ;

Maeda, Yoshinobu ;

Hashimoto, Chizuko ;

Ishida, Fumihiro ;

Izutsu, Koji ;

Fukushima, Noriyasu ;

Isobe, Yasushi ;

Takizawa, Jun ;

Hasegawa, Yuichi ;

Kobayashi, Hajime ;

Okamura, Seiichi ;

Kobayashi, Hikaru ;

Yamaguchi, Motoko ;

Suzumiya, Junji ;

Hyo, Rie ;

Nakamura, Shigeo ;

Kawa, Keisei ;

Oshimi, Kazuo ;

Suzuki, Ritsuro .

CLINICAL CANCER RESEARCH, 2012, 18 (15) :4183-4190

← 1 2 3 4 →