A poly(vinyl chloride) membrane electrode for the determination of the diuretic furosemide

被引：27
|
作者：
Dias, ILT
Neto, GD
Vendramini, DC
Sommer, C
Martins, JLS
Kubota, LT
机构：
[1] Univ Sao Francisco, UAACBS, Curso Farm, BR-12916900 Braganca Paulista, SP, Brazil
[2] Univ Sao Paulo, Fac Ciencias Farmaceut, Sao Paulo, Brazil
[3] Univ Estadual Campinas, Inst Quim, Campinas, SP, Brazil
来源：
ANALYTICAL LETTERS | 2004年 / 37卷 / 01期
关键词：
furosemide; poly(vinyl chloride) membrane electrode; ion-selective electrode; direct potentiometry; pharmaceutical analysis;
D O I：
10.1081/AL-120027772
中图分类号：
O65 [分析化学];
学科分类号：
070302 ; 081704 ;
摘要：
New polymeric electrode responding to furosemide was constructed by incorporating the furosemide-aliquat ion pair complex into a poly(vinyl chloride) (PVC) membrane. The electrode exhibited a linear response over the concentration range 1.59 x 10(-4)-1.00 X 10(-2) mol L-1, a detection limit Of,. 19 X 10(-4) mol L-1 with E = - 245.6 - 58.9log[Fur]. The pH did not affect the response of the electrode within the range 7.0-10.0. Direct potentiometry was used to assay furosemide in pharmaceutical preparations. The results were compared with those obtained with spectrophotometric and chromatographic reference methods.
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页码：35 / 46
页数：12
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