Sensitivity enhanced nanothermal sensors for photoacoustic temperature mapping

被引:29
作者
Chen, Yun-Sheng [1 ]
Frey, Wolfgang [1 ]
Walker, Charles [1 ]
Aglyamov, Salavat [1 ]
Emelianov, Stanislav [1 ,2 ]
机构
[1] Univ Texas Austin, Dept Biomed Engn, Austin, TX 78712 USA
[2] Univ Texas Austin, Dept Elect & Comp Engn, Austin, TX 78712 USA
基金
美国国家卫生研究院; 美国国家科学基金会;
关键词
photoacoustics; temperature mapping; temperature sensor; silica-coated gold nanorods; INTENSITY FOCUSED ULTRASOUND; SMALL HEPATOCELLULAR-CARCINOMA; MICROWAVE COAGULATION THERAPY; RADIOFREQUENCY ABLATION; PHOTOTHERMAL THERAPY; GOLD NANORODS; CANCER; NANOPARTICLES; GROWTH; CONJUGATION;
D O I
10.1002/jbio.201200219
中图分类号
Q5 [生物化学];
学科分类号
071010 ; 081704 ;
摘要
Photoacoustic imaging can be used to guide and validate the therapeutic outcome of nanoparticle-mediated photothermal therapy through its ability to visualize the delivery of nanoparticle contrast agents, image the temperature distribution inside living tissue, and confirm tissue coagulation. In this image-guided process, temperature mapping plays a critical role for thermal dosage control. Therefore, developing a sensitive and accurate photoacoustic technique to quantitatively measure the temperature distribution during thermal therapy is essential. In this study, we investigated and demonstrated that silica-coated gold nanorods, can provide a multi-fold improvement in sensitivity of the photoacoustic temperature mapping compared to gold nanorods without silica coating, and serve as a nanothermal sensor to accurately and quantitatively visualize temperature distributions during photothermal therapy. ((c) 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim)
引用
收藏
页码:534 / 542
页数:9
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