Cholecystokinin-mediated suppression of feeding involves the brainstem melanocortin system

被引：240

作者：

Fan, W ^{[1
]}

Ellacott, KLJ ^{[1
]}

Halatchev, IG ^{[1
]}

Takahashi, K ^{[1
]}

Yu, PX ^{[1
]}

Cone, RD ^{[1
]}

机构：

[1] Oregon Hlth & Sci Univ, Vollum Inst, Portland, OR 97239 USA

来源：

NATURE NEUROSCIENCE | 2004年 / 7卷 / 04期

关键词：

D O I：

10.1038/nn1214

中图分类号：

Q189 [神经科学];

学科分类号：

071006 ;

摘要：

Hypothalamic pro-opiomelanocortin (POMC) neurons help regulate long-term energy stores. POMC neurons are also found in the nucleus tractus solitarius (NTS), a region regulating satiety. We show here that mouse brainstem NTS POMC neurons are activated by cholecystokinin (CCK) and feeding-induced satiety and that activation of the neuronal melanocortin-4 receptor (MC4-R) is required for CCK-induced suppression of feeding; the melanocortin system thus provides a potential substrate for integration of long-term adipostatic and short-term satiety signals.

引用

页码：335 / 336

页数：2

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