Total synthesis of marine derived natural toxin, ''brevetoxin B''

被引：2

作者：

Sato, M

机构：

[1] UNITIKA R and D Center, Kyoto 611

来源：

JOURNAL OF SYNTHETIC ORGANIC CHEMISTRY JAPAN | 1997年 / 55卷 / 08期

关键词：

brevetoxin B; maitotoxin; total synthesis; Gymnodinium breve Davis; Prof; K.C; Nicolaou; The Scripps Research Institute; University of California; San Diego;

D O I：

10.5059/yukigoseikyokaishi.55.686

中图分类号：

O62 [有机化学];

学科分类号：

070303 ; 081704 ;

摘要：

Brevetoxin B(1), isolated from dinofiagellate, Gymnodinium breve Davis, has been known as a potent neurotoxin which affect to the current of Na ion of the Na channel. The total synthesis ai this complex compound that includes 11 trans-fused rings and 23 stereocenters was completed under the conduction of Prof. Nicolaou in 0.043% total yield (91% average yields) from 2-deoxy-D-ribose after more than 10 years struggle. I herein wish to report the strategies and synthetic routes, both failed and successful, toward this destination.

引用

页码：686 / 696

页数：11

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