Total synthesis of marine derived natural toxin, ''brevetoxin B''

Brevetoxin B(1), isolated from dinofiagellate, Gymnodinium breve Davis, has been known as a potent neurotoxin which affect to the current of Na ion of the Na channel. The total synthesis ai this complex compound that includes 11 trans-fused rings and 23 stereocenters was completed under the conduction of Prof. Nicolaou in 0.043% total yield (91% average yields) from 2-deoxy-D-ribose after more than 10 years struggle. I herein wish to report the strategies and synthetic routes, both failed and successful, toward this destination.