Synthesis and Application of β-Substituted Pauson-Khand Adducts: Trifluoromethyl as a Removable Steering Group

被引：25

作者：

Aiguabella, Nuria ^{[1
]}

del Pozo, Carlos ^{[3
,4
]}

Verdaguer, Xavier ^{[1
,2
]}

Fustero, Santos ^{[3
,4
]}

Riera, Antoni ^{[1
,2
]}

机构：

[1] Inst Res Biomed IRB Barcelona, Barcelona 08028, Spain

[2] Univ Barcelona, Dept Quim Organ, E-08028 Barcelona, Spain

[3] Univ Valencia, Dept Quim Organ, E-46100 Burjassot, Spain

[4] Ctr Invest Principe Felipe, Lab Mol Organ, Valencia 46012, Spain

来源：

ANGEWANDTE CHEMIE-INTERNATIONAL EDITION | 2013年 / 52卷 / 20期

关键词：

directing group; PausonKhand reaction; regioselectivity; synthetic methods; trifluoromethyl alkynes; ENANTIOSELECTIVE RING CONSTRUCTION; CONJUGATE ADDITION; EFFICIENT; (-)-ALPHA-CUPARENONE; REGIOSELECTIVITY; CARBON; REGIOCHEMISTRY; REACTIVITY; COMPLEXES; LIGANDS;

D O I：

10.1002/anie.201300907

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

Against the rules: The synthesis of the previously unknown β-substituted regioisomers of the intermolecular Pauson-Khand reaction of terminal alkynes is reported. This regiochemistry was achieved by using the trifluoromethyl group as a removable directing group on the alkyne. Copyright © 2013 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim.

引用

页码：5355 / 5359

页数：5

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