A Practical and Benign Synthesis of Primary Amines through Ruthenium-Catalyzed Reduction of Nitriles

被引：98

作者：

Enthaler, Stephan ^{[1
]}

Junge, Kathrin ^{[2
]}

Addis, Daniele ^{[2
]}

Erre, Giulia ^{[3
]}

Beller, Matthias ^{[2
]}

机构：

[1] MIT, Dept Chem, Cambridge, MA 02139 USA

[2] Univ Rostock, Leibniz Inst Katalyse eV, D-18059 Rostock, Germany

[3] Rhein Westfal TH Aachen, ITMC, CAT Catalyt Ctr, D-52074 Aachen, Germany

来源：

CHEMSUSCHEM | 2008年 / 1卷 / 12期

关键词：

amines; homogeneous catalysis; hydrogenation; nitriles; ruthenium;

D O I：

10.1002/cssc.200800185

中图分类号：

O6 [化学];

学科分类号：

0703 ;

摘要：

The catalytic hydrogenation of nitriles represents an atom-economic and valuable route to amines. In the present study, the ruthenium-catalyzed hydrogenation of various organic nitriles to give primary amines has been examined in detail. Straightforward ruthenium complexes modified by cheap and widely available triphenylphosphine allow for the efficient and general reduction of various aryl, alkyl, and heterocyclic nitriles. By using a practical in situ catalyst composed of [Ru(cod)(methylallyl(2))] and PPh3, excellent yields and chemoselectivity were achieved. Moreover, the catalyst system displays broad functional group tolerance.

引用

页码：1006 / 1010

页数：5

共 58 条

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