Fatigue in multiple sclerosis: Cross-sectional correlation with brain MRI findings in 71 patients

被引：152

作者：

Bakshi, R

Miletich, RS

Henschel, K

Shaikh, ZA

Janardhan, V

Wasay, M

Stengel, LM

Ekes, R

Kinkel, PR

机构：

[1] Kaleida Hlth Millard Fillmore Hosp, Imaging Serv, Dent Neurol Inst, Buffalo, NY USA

[2] SUNY Buffalo, Dept Neurol, Buffalo, NY 14260 USA

来源：

NEUROLOGY | 1999年 / 53卷 / 05期

关键词：

MRI; fatigue; MS;

D O I：

10.1212/WNL.53.5.1151

中图分类号：

R74 [神经病学与精神病学];

学科分类号：

摘要：

Fatigue is am unexplained but common and disabling symptom in MS. We assessed fatigue in 71 patients with MS and identified MS-fatigue (MSF) and MS-nonfatigue (MSNF) groups. Fatigue severity did not correlate with regional or global MRI plaque load or atrophy assessed by conventional sequences. No significant differences were noted in any MRI measures between MSF and MSNF groups. We suggest that brain MRI disease topography or severity does not explain fatigue in MS and that fatigue is likely due to mechanisms poorly characterized by conventional MRI.

引用

收藏

页码：1151 / 1153

页数：3

相关论文

共 10 条

[1]

Bakshi R, 1999, NEUROLOGY, V52, pA361

[2] High-resolution fluorodeoxyglucose positron emission tomography shows both global and regional cerebral hypometabolism in multiple sclerosis [J].

Bakshi, R ;

Miletich, RS ;

Kinkel, PR ;

Emmet, ML ;

Kinkel, WR .

JOURNAL OF NEUROIMAGING, 1998, 8 (04) :228-234

[3] THE IMPACT OF FATIGUE ON PATIENTS WITH MULTIPLE-SCLEROSIS [J].

FISK, JD ;

PONTEFRACT, A ;

RITVO, PG ;

ARCHIBALD, CJ ;

MURRAY, TJ .

CANADIAN JOURNAL OF NEUROLOGICAL SCIENCES, 1994, 21 (01) :9-14

[4]

Grossman RI, 1998, AM J NEURORADIOL, V19, P1251

[5] THE FATIGUE SEVERITY SCALE - APPLICATION TO PATIENTS WITH MULTIPLE-SCLEROSIS AND SYSTEMIC LUPUS-ERYTHEMATOSUS [J].

KRUPP, LB ;

LAROCCA, NG ;

MUIRNASH, J ;

STEINBERG, AD .

ARCHIVES OF NEUROLOGY, 1989, 46 (10) :1121-1123

[6] FATIGUE THERAPY IN MULTIPLE-SCLEROSIS - RESULTS OF A DOUBLE-BLIND, RANDOMIZED, PARALLEL TRIAL OF AMANTADINE, PEMOLINE, AND PLACEBO [J].

KRUPP, LB ;

COYLE, PK ;

DOSCHER, C ;

MILLER, A ;

CROSS, AH ;

JANDORF, L ;

HALPER, J ;

JOHNSON, B ;

MORGANTE, L ;

GRIMSON, R .

NEUROLOGY, 1995, 45 (11) :1956-1961

[7] FATIGUE IN MULTIPLE-SCLEROSIS [J].

KRUPP, LB ;

ALVAREZ, LA ;

LAROCCA, NG ;

SCHEINBERG, LC .

ARCHIVES OF NEUROLOGY, 1988, 45 (04) :435-437

[8] CORRELATES OF COGNITIVE IMPAIRMENT AND DEPRESSIVE MOOD DISORDER IN MULTIPLE-SCLEROSIS [J].

MOLLER, A ;

WIEDEMANN, G ;

ROHDE, U ;

BACKMUND, H ;

SONNTAG, A .

ACTA PSYCHIATRICA SCANDINAVICA, 1994, 89 (02) :117-121

[9] Reduced glucose metabolism in the frontal cortex and basal ganglia of multiple sclerosis patients with fatigue: A F-18-fluorodeoxyglucose positron emission tomography study [J].

Roelcke, U ;

Kappos, L ;

LechnerScott, J ;

Brunnschweiler, H ;

Huber, S ;

Ammann, W ;

Plohmann, A ;

Dellas, S ;

Maguire, RP ;

Missimer, J ;

Radu, EW ;

Steck, A ;

Leenders, KL .

NEUROLOGY, 1997, 48 (06) :1566-1571

[10] Treatment with weak electromagnetic fields improves fatigue associated with multiple sclerosis [J].

Sandyk, R .

INTERNATIONAL JOURNAL OF NEUROSCIENCE, 1996, 84 (1-4) :177-186