In vitro anti-inflammatory activity of carvacrol: Inhibitory effect on COX-2 catalyzed prostaglandin E2 biosynthesisb

被引：134

作者：

Landa, Premysl ^{[1
,2
]}

Kokoska, Ladislav ^{[3
]}

Pribylova, Marie ^{[1
,2
]}

Vanek, Tomas ^{[1
,2
]}

Marsik, Petr ^{[1
,2
]}

机构：

[1] Inst Expt Bot AS CR, Joint Lab, Plant Biotechnol Lab, Prague 16502 6, Lysolaje, Czech Republic

[2] Res Inst Crop Prod, Prague 16502 6, Lysolaje, Czech Republic

[3] Czech Univ Life Sci Prague, Inst Trop & Subtrop, Dept Crop Sci & Agroforestry, Prague 16521 6, Suchdol, Czech Republic

来源：

ARCHIVES OF PHARMACAL RESEARCH | 2009年 / 32卷 / 01期

关键词：

Carvacrol; Cyclooxygenase; Prostaglandin; Inhibition; Anti-inflammatory; ANTIMICROBIAL ACTIVITY; CONSTITUENTS; THYMOL; SEEDS;

D O I：

10.1007/s12272-009-1120-6

中图分类号：

R914 [药物化学];

学科分类号：

100701 ;

摘要：

Possible anti-inflammatory effect of carvacrol was evaluated by in vitro cyclooxygenase-2 (COX-2) assay. Carvacrol inhibited production of prostaglandin E-2 catalysed by COX-2 with an IC50 value of 0.8 mu M what is practically the same concentration as the IC50 obtained for the standard inhibitors indomethacin and NS-398 with values of 0.7 mu M and 0.8 mu M, respectively. The COX-1 was inhibited approximately at the same rate (IC50 of 0.7 mu M for carvacrol), which suggests non-selective inhibition of both enzyme isoforms. The results of the study demonstrate possible anti-inflammatory potential of this compound due to the inhibition of inducible COX-2 isoform.

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收藏

页码：75 / 78

页数：4

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