Evaluation of residual monomer release and toxicity of self-adhesive resin cements

被引：46
作者：
Kurt, Aysegul [1 ]
Altintas, Subutay Han [2 ]
Kiziltas, Mustafa Volkan [3 ]
Tekkeli, Serife Evrim [3 ]
Guler, Eray Metin [4 ]
Kocyigit, Abdurrahim [4 ]
Usumez, Aslihan [5 ]
机构：
[1] Trakya Univ, Dept Prosthodont, Fac Dent, TR-22030 Edirne, Turkey
[2] Karadeniz Tech Univ, Dept Prosthodont, Fac Dent, TR-61080 Trabzon, Turkey
[3] Bezmialem Vakif Univ, Dept Analyt Chem, Fac Pharm, TR-34093 Istanbul, Turkey
[4] Bezmialem Vakif Univ, Fac Med, Dept Med Biochem, TR-34093 Istanbul, Turkey
[5] Bezmialem Vakif Univ, Dept Prosthodont, Fac Dent, TR-34093 Istanbul, Turkey
来源：
DENTAL MATERIALS JOURNAL | 2018年 / 37卷 / 01期
关键词：
Self-adhesive resin cement; Monomer release; Cytotoxicity; Genotoxicity; ELECTROPHORESIS COMET ASSAY; HUMAN GINGIVAL FIBROBLASTS; SEALANTS IN-VITRO; DENTAL COMPOSITE; DNA-DAMAGE; PULP CELLS; CYTOTOXICITY; COMPONENTS; LYMPHOCYTES; GLUTATHIONE;
D O I：
10.4012/dmj.2016-380
中图分类号：
R78 [口腔科学];
学科分类号：
1003 ;
摘要：
The aim of this study was to evaluate the amount of leached residual monomers from self-adhesive resin cements and evaluate their toxicity in-vitro. A total of 60 disk-shaped specimens (5 mm in diameter and 0.5 mm in thickness) were prepared from each cement (RelyX U200, SpeedCEM, G-Cem) (n=20). Specimens were immersed in artificial saliva and the amount of released monomers [urethane dimethacrylate (UDMA) and triethyleneglycol dimethacrylate (TEGDMA)] was identified. Then, the cytotoxicity and genotoxicity effect on cells were evaluated using the defined amounts of released monomers from cements. The highest monomer release was detected in G-Cem (p<0.05). The highest cytotoxicity value was identified from SpeedCEM (p<0.01) and the highest genotoxicity values were calculated from RelyX U200 (p<0.05). Released UDMA and TEGDMA from self-adhesive resin cements induced cytotoxicity and genotoxicity effect on cells.
引用
收藏
页码：40 / 48
页数：9
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