Synthesis and antiproliferative activities of diversely substituted glycosyl-isoindigo derivatives

被引：56
|
作者：
Sassatelli, M
Bouchikhi, F
Messaoudi, S
Anizon, F
Debiton, E
Barthomeuf, C
Prudhomme, M
Moreau, P
机构：
[1] Univ Clermont Ferrand, CNRS, Lab SEESIB, UMR 6504, F-63177 Aubiere, France
[2] Univ Auvergne, Ctr Jean Perrin, INSERM, UMR 484,Lab Pharmacog Biotechnol, F-63005 Clermont Ferrand, France
来源：
EUROPEAN JOURNAL OF MEDICINAL CHEMISTRY | 2006年 / 41卷 / 01期
关键词：
indigoids; isoindigos; antiproliferative activities;
D O I：
10.1016/j.ejmech.2005.10.004
中图分类号：
R914 [药物化学];
学科分类号：
100701 ;
摘要：
in the course of structure-activity relationship studies, diversely substituted 1-(beta-(D)-glucopyranosyl)-isoindigo derivatives were prepared from commercially available indolines. Their antiproliferative activities were evaluated toward a panel of human solid cancer cell lines (PC 3, DLD-1, MCF-7, M4Beu, A549, PA 1), a murine cell line (L929) and a human fibroblast primary culture to get an insight into the substitution pattern required for the best biological potencies. (c) 2005 Elsevier SAS. All rights reserved.
引用
收藏
页码：88 / 100
页数：13
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