Subjective cognitive complaints and amyloid burden in cognitively normal older individuals

被引：389

作者：

Amariglio, Rebecca E. ^{[1
,2
]}

Becker, J. Alex ^{[3
]}

Carmasin, Jeremy ^{[3
]}

Wadsworth, Lauren P. ^{[2
]}

Lorius, Natacha ^{[1
,2
]}

Sullivan, Caroline ^{[2
]}

Maye, Jacqueline E. ^{[3
]}

Gidicsin, Christopher ^{[3
]}

Pepin, Lesley C. ^{[3
]}

Sperling, Reisa A. ^{[1
,2
]}

Johnson, Keith A. ^{[1
,2
,3
]}

Rentz, Dorene M. ^{[1
,2
]}

机构：

[1] Brigham & Womens Hosp, Div Cognit & Behav Neurol, Dept Neurol, Boston, MA 02115 USA

[2] Harvard Univ, Sch Med, Dept Neurol, Massachusetts Gen Hosp, Boston, MA 02115 USA

[3] Harvard Univ, Sch Med, Dept Radiol, Massachusetts Gen Hosp, Boston, MA 02115 USA

来源：

NEUROPSYCHOLOGIA | 2012年 / 50卷 / 12期

关键词：

Preclinical Alzheimer's disease; Early detection; Amyloid imaging; Subjective cognitive complaints; MEMORY COMPLAINTS; ALZHEIMERS-DISEASE; IMPAIRMENT; DEPOSITION; DEMENTIA; PERFORMANCE; DECLINE; ATROPHY; VOLUME; VALIDATION;

D O I：

10.1016/j.neuropsychologia.2012.08.011

中图分类号：

B84 [心理学]; C [社会科学总论]; Q98 [人类学];

学科分类号：

03 ; 0303 ; 030303 ; 04 ; 0402 ;

摘要：

Accumulating evidence suggests that subjective cognitive complaints (SCC) may indicate subtle cognitive decline characteristic of individuals with preclinical Alzheimer's disease (AD). In this study, we sought to build upon previous studies by associating SCC and amyloid-beta deposition using positron emission tomography with Pittsburgh Compound B (PiB-PET) in cognitively normal older individuals. One-hundred thirty one subjects (mean age 73.5 +/- 6) were administered three subjective cognitive questionnaires and a brief neuropsychological battery. A relationship between a subjective memory complaints composite score and cortical PiB binding was found to be significant, even after controlling for depressive symptoms. By contrast, there were no significant relationships between objective cognitive measures of memory and executive functions and cortical PiB binding. Our study suggests that SCC may be an early indicator of AD pathology detectable prior to significant objective impairment. (C) 2012 Elsevier Ltd. All rights reserved.

引用

页码：2880 / 2886

页数：7

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