Genetic approaches to reveal the connectivity of adult-born neurons

被引:7
作者
Arenkiel, Benjamin R. [1 ,2 ,3 ]
机构
[1] Baylor Coll Med, Dept Mol & Human Genet, Houston, TX 77030 USA
[2] Baylor Coll Med, Dept Neurosci, Houston, TX 77030 USA
[3] Texas Childrens Hosp, Baylor Coll Med, Jan & Dan Duncan Neurol Res Inst, Houston, TX 77030 USA
来源
FRONTIERS IN NEUROSCIENCE | 2011年 / 5卷
关键词
neurogenesis; synapse; circuit; viruses; optogenetics; heterologous; trans-synaptic; monosynaptic;
D O I
10.3389/fnins.2011.00048
中图分类号
Q189 [神经科学];
学科分类号
071006 ;
摘要
Much has been learned about the environmental and molecular factors that influence the division, migration, and programmed cell death of adult-born neurons in the mammalian brain. However, detailed knowledge of the mechanisms that govern the formation and maintenance of functional circuit connectivity via adult neurogenesis remains elusive. Recent advances in genetic technologies now afford the ability to precisely target discrete brain tissues, neuronal subtypes, and even single neurons for vital reporter expression and controlled activity manipulations. Here, I review current viral tracing methods, heterologous receptor expression systems, and optogenetic technologies that hold promise toward elucidating the wiring diagrams and circuit properties of adult-born neurons.
引用
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页数:8
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