Antiviral activity of phosvitin from zebrafish Danio rerio

被引：18
作者：
Sun, Chen
Hu, Lili
Liu, Shousheng
Hu, Guobin
Zhang, Shicui [1 ]
机构：
[1] Ocean Univ China, Lab Evolut & Dev, Inst Evolut & Marine Biodivers, Qingdao 266003, Peoples R China
来源：
DEVELOPMENTAL AND COMPARATIVE IMMUNOLOGY | 2013年 / 40卷 / 01期
基金：
中国博士后科学基金;
关键词：
Zebrafish; Phosvitin; Lymphocystis disease virus (LCDV); Antiviral activity; Vitellogenin; FLOUNDER PARALICHTHYS-OLIVACEUS; JAPANESE FLOUNDER; LYMPHOCYSTIS VIRUS; EXPRESSION; SEQUENCE; RECEPTOR; GENOME; GILL;
D O I：
10.1016/j.dci.2012.12.009
中图分类号：
S9 [水产、渔业];
学科分类号：
0908 ;
摘要：
Lymphocystis disease virus (LCDV), a virus of Iridoviridae, can infect numerous teleost species, causing serious losses of aquaculture industry, and thus effective ways of prophylaxis and treatment are demanded. Previous studies have shown that phosvitin (Pv) is an antimicrobial agent in zebrafish, and vitellogenin, the precursor of yolk proteins including Pv, is able to neutralize virus, we thus hypothesize that Pv may have an antiviral activity. Here we clearly demonstrated that recombinant Pv (rPv) purified was capable of inhibiting the cytopathic effect in LCDV-infected cells and reducing the virus quantities in the infected cells as well as in the infected zebrafish. These data indicate that Pv possesses an antiviral activity and participates in immune defense of host against the infection by viruses like LCDV. (c) 2013 Elsevier Ltd. All rights reserved.
引用
收藏
页码：28 / 34
页数：7
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