The safety of high-dose buprenorphine administered subcutaneously in cats

被引:16
作者
Sramek, M. K. [1 ]
Haas, M. C. [2 ]
Coleman, G. D. [2 ]
Atterson, P. R. [2 ]
Hamlin, R. L. [3 ]
机构
[1] Abbott Labs, Abbott Pk, IL 60064 USA
[2] WIL Res, Ashland, OH USA
[3] QTest Labs LLC, Columbus, OH USA
关键词
POSTOPERATIVE ANALGESIA; OVARIOHYSTERECTOMY; BUTORPHANOL; EFFICACY; MORPHINE; PAIN; BUPIVACAINE; CARPROFEN; HYDROCHLORIDE; PHARMACOLOGY;
D O I
10.1111/jvp.12203
中图分类号
R9 [药学];
学科分类号
1007 ;
摘要
The safety of a proprietary formulation of buprenorphine hydrochloride administered subcutaneously (SC) to young cats was investigated in a blinded, randomized study. Four cohorts of eight cats aged approximately 4months were administered saline, 0.24, 0.72 or 1.20mg/kg/day buprenorphine SC for nine consecutive days, representing 0x, 1x, 3x and 5x of the intended dose. Cats were monitored daily for evidence of clinical reactions, food and water intake and adverse events (AEs). Physical examinations, clinical pathology, vital signs and electrocardiograms (ECGs) were evaluated at protocol-specified time points. Complete necropsy and histopathologic examinations were performed following humane euthanasia. Four buprenorphine-treated cats experienced AEs during the study, two unrelated and two related to study drug administration. The two cats with AEs considered related to drug administration had clinical signs of hyperactivity, difficulty in handling, disorientation, agitation and dilated pupils in one 0.24mg/kg/day cat and one 0.72mg/kg/day cat. All of these clinical signs were observed simultaneously. There were no drug-related effects on survival, injection response, injection site inspections, body weight, food or water consumption, bleeding time, urinalysis, respiration rate, heart rate, ECGs, blood pressures, body temperatures, macroscopic examinations or organ weights. Once daily buprenorphine s.c. injections at doses of 0.24, 0.72 and 1.20mg/kg/day for 9consecutive days were well tolerated in young domestic cats.
引用
收藏
页码:434 / 442
页数:9
相关论文
共 31 条
[1]   Cardiopulmonary effects of three different anaesthesia protocols in cats [J].
Akkerdaas, LC ;
Mioch, P ;
Sap, R ;
Hellebrekers, LJ .
VETERINARY QUARTERLY, 2001, 23 (04) :182-186
[2]   Comparison of the efficacy and adverse effects of sustained-release buprenorphine hydrochloride following subcutaneous administration and buprenorphine hydrochloride following oral transmucosal administration in cats undergoing ovariohysterectomy [J].
Catbagan, Davina L. ;
Quimby, Jessica M. ;
Mama, Khursheed R. ;
Rychel, Jessica K. ;
Mich, Patrice M. .
AMERICAN JOURNAL OF VETERINARY RESEARCH, 2011, 72 (04) :461-466
[3]   ANIMAL PHARMACOLOGY OF BUPRENORPHINE, AN ORIPAVINE ANALGESIC AGENT [J].
COWAN, A ;
DOXEY, JC ;
HARRY, EJR .
BRITISH JOURNAL OF PHARMACOLOGY, 1977, 60 (04) :547-554
[4]  
Cowan A, 2003, INT J CLIN PRACT, P3
[5]   Evaluation of signs of postoperative pain and complications after forelimb onychectomy in cats receiving buprenorphine alone or with bupivacaine administered as a four-point regional nerve block [J].
Curcio, K ;
Bidwell, LA ;
Bohart, GV ;
Hauptman, JG .
JAVMA-JOURNAL OF THE AMERICAN VETERINARY MEDICAL ASSOCIATION, 2006, 228 (01) :65-68
[6]   Comparison of the effects of buprenorphine, oxymorphone hydrochloride, and ketoprofen for postoperative analgesia after onychectomy or onychectomy and sterilization in cats [J].
Dobbins, S ;
Brown, NO ;
Shofer, FS .
JOURNAL OF THE AMERICAN ANIMAL HOSPITAL ASSOCIATION, 2002, 38 (06) :507-514
[7]   EFFECTS OF SUBACUTE OPIOID ADMINISTRATION DURING LATE PREGNANCY IN THE RAT ON THE INITIATION, DURATION AND OUTCOME OF PARTURITION AND MATERNAL LEVELS OF OXYTOCIN AND ARGININE VASOPRESSIN [J].
EVANS, RG ;
OLLEY, JE ;
RICE, GE ;
ABRAHAMS, JM .
CLINICAL AND EXPERIMENTAL PHARMACOLOGY AND PHYSIOLOGY, 1989, 16 (03) :169-178
[8]   Postoperative analgesic effects of intravenous, intramuscular, subcutaneous or oral transmucosal buprenorphine administered to cats undergoing ovariohysterectomy [J].
Giordano, Tatiana ;
Steagall, Paulo V. M. ;
Ferreira, Tatiana H. ;
Minto, Bruno W. ;
Rodolfo de Sa Lorena, Silvia Elaine ;
Brondani, Juliana ;
Luna, Stelio P. L. .
VETERINARY ANAESTHESIA AND ANALGESIA, 2010, 37 (04) :357-366
[9]   Investigating medetomidine-buprenorphine as preanaesthetic medication in cats [J].
Grint, N. J. ;
Burford, J. ;
Dugdale, A. H. A. .
JOURNAL OF SMALL ANIMAL PRACTICE, 2009, 50 (02) :73-81
[10]   BUPRENORPHINE - REVIEW OF ITS PHARMACOLOGICAL PROPERTIES AND THERAPEUTIC EFFICACY [J].
HEEL, RC ;
BROGDEN, RN ;
SPEIGHT, TM ;
AVERY, GS .
DRUGS, 1979, 17 (02) :81-110