Sesquiterpenoids from Curcuma wenyujin with anti-influenza viral activities

被引：41
作者：
Dong, Jian-Yong [1 ]
Ma, Xi-Yan [1 ]
Cai, Xiao-Qin [2 ]
Yan, Peng-Cheng [1 ]
Yue, Lei [1 ]
Lin, Chen [1 ]
Shao, Wei-Wei [1 ]
机构：
[1] Wenzhou Med Coll, Sch Pharm, Wenzhou 325035, Peoples R China
[2] Wenzhou Univ, Wenzhou 325035, Peoples R China
来源：
PHYTOCHEMISTRY | 2013年 / 85卷
关键词：
Curcuma wenyujin; Zingiberaceae; Sesquiterpenoid; Guaiane; Seco-guaiane; Cadinane; Germacrane; Eudesmane; Anti-influenza viral A activity; NITRIC-OXIDE PRODUCTION; INFLUENZA-VIRUS; INHIBITORS; STEREOSTRUCTURE; CURDIONE;
D O I：
10.1016/j.phytochem.2012.09.008
中图分类号：
Q5 [生物化学]; Q7 [分子生物学];
学科分类号：
071010 ; 081704 ;
摘要：
Five sesquiterpenoids, 1 alpha,8 alpha-epidioxy-4 alpha-hydroxy- 5 alpha H-guai-7(11),9-dien- 12,8-olide. (1), 8,9-seco-4 beta-hydroxy-1 alpha,5 beta H-7(11)-guaen-8,10-olide (2), 8 alpha-hydroxy-1 alpha, 4 beta,7 beta H-guai-10(15)-en- 5 beta,8 beta-endoxide(3), 7 beta,8 alpha-dihydroxy-1 alpha,4 alpha H-guai-10(15)-en-5 beta,8 beta-endoxide(4) and 7-hydroxy-5(10),6,8-cadinatriene-4-one(5), together with seven known analogs were isolated from the rhizomes of Curcurna wenyujin. Their structures and relative configurations were determined on the basis of spectroscopic methods including 2D NMR techniques, and the structures of 1 and 2 were confirmed by single-crystal X-ray diffraction experiment. Compounds 1-10 and 12 showed significant in vitro antiviral activity against the influenza virus A with IC50 values ranged from 6.80 to 39.97 mu M, and SI values ranged from 635 to 37.25. (C) 2012 Elsevier Ltd. All rights reserved.
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页码：122 / 128
页数：7
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