Clinical effects of heliox administration for acute bronchiolitis in young infants

被引:47
作者
Cambonie, G
Milési, C
Fournier-Favre, S
Counil, F
Jaber, S
Picaud, JC
Matecki, S
机构
[1] CHU Montpellier, Hop Arnaud Villeneuve, Unite Reanimat Pediat, F-34295 Montpellier 5, France
[2] Univ Hosp Montpellier, St Eloi Hosp, Intens Care Unit, Montpellier, France
[3] Univ Hosp Montpellier, St Eloi Hosp, Dept Transplantat, Montpellier, France
关键词
bronchiolitis; helium; infant; randomized controlled trial; respiratory syncytial virus infections; respiratory therapy;
D O I
10.1378/chest.129.3.676
中图分类号
R4 [临床医学];
学科分类号
1002 ; 100602 ;
摘要
Objective: To assess the effect of heliox, a helium-oxygen mixture, on respiratory distress symptoms in young,infants. Design: Prospective randomized, double-blind study. Setting: Pediatric ICU (PICU) of a university hospital. Patients: Twenty infants, all < 3 months old, admitted to the PICU with moderate-to-severe acute respiratory syncytial virus bronchiolitis. Interventions: All infants were randomly and blindly assigned to inhale either heliox or an air-oxygen mixture (airox) for 1 h under an oxyhood. Measurements and results: After 1 h, the respiratory distress score was significantly lower in the heliox group compared with the airox group (3.05 vs 5.5, p < 0.01), with a significant reduction in accessory muscles use (p < 0.05) and expiratory wheezing (p < 0.01). In contrast, inspiratory breath sounds and cyanosis did not significantly differ between groups. The ex-premature infants of the heliox group had a higher respiratory distress score at baseline compared with the term infants of this group (5.8 vs 5.2, p < 0.05) and a comparable decrease in the score at 60 min. Conclusions: In young infants, even those born prematurely, heliox breathing induced a rapid reduction in accessory muscles use and expiratory wheezing. Further studies are needed to confirm the decreased respiratory muscle work of breathing during heliox inhalation in this population.
引用
收藏
页码:676 / 682
页数:7
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